Predicted to enable DNA binding activity. Involved in DNA replication initiation and DNA replication, synthesis of primer. Located in ciliary basal body; cytosol; and nucleoplasm. Part of alpha DNA polymerase:primase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POLA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POLA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POLA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:64,971,835–64,972,454 | 289.8 kb | Distal (>10kb) Multiome | 265 | |
| chr11:65,013,538–65,014,838 | 247.9 kb | Distal (>10kb) Multiome | 980 | |
| chr11:65,027,243–65,027,944 | 234.3 kb | Distal (>10kb) Multiome | 851 | |
| chr11:65,040,595–65,041,884 | 220.8 kb | Distal (>10kb) Multiome | 838 | |
| chr11:65,083,636–65,084,788 | 177.7 kb | Distal (>10kb) Multiome | 898 | |
| chr11:65,095,834–65,097,052 | 165.4 kb | Distal (>10kb) Multiome | 1061 | |
| chr11:65,111,466–65,113,404 | 150.1 kb | Distal (>10kb) Multiome | 919 | |
| chr11:65,116,528–65,118,298 | 144.1 kb | Distal (>10kb) Multiome | 973 | |
| chr11:65,121,474–65,122,848 | 139.7 kb | Distal (>10kb) Multiome | 817 | |
| chr11:65,134,120–65,135,530 | 126.9 kb | Distal (>10kb) Multiome | 997 | |
| chr11:65,180,773–65,182,676 | 80.2 kb | Distal (>10kb) Multiome | 832 | |
| chr11:65,184,109–65,184,542 | 77.6 kb | Distal (>10kb) Multiome | 85 | |
| chr11:65,213,383–65,213,853 | 48.2 kb | Distal (>10kb) Multiome | 174 | |
| chr11:65,225,439–65,226,037 | 36.3 kb | Distal (>10kb) Multiome | 522 | |
| chr11:65,261,186–65,262,526 | 91 bp | At TSS Multiome | 777 | |
| chr11:65,314,302–65,316,053 | 53.8 kb | Distal (>10kb) Multiome HiCAR | 803 | |
| chr11:65,333,360–65,334,372 | 71.9 kb | Distal (>10kb) Multiome | 654 | |
| chr11:65,354,023–65,355,987 | 92.7 kb | Distal (>10kb) Multiome | 677 | |
| chr11:65,366,306–65,366,977 | 104.7 kb | Distal (>10kb) Multiome | 309 | |
| chr11:65,381,835–65,382,758 | 120.3 kb | Distal (>10kb) Multiome | 984 | |
| chr11:65,386,320–65,387,097 | 124.7 kb | Distal (>10kb) Multiome | 757 | |
| chr11:65,416,383–65,417,015 | 154.6 kb | Distal (>10kb) Multiome | 664 | |
| chr11:65,417,855–65,419,687 | 157.2 kb | Distal (>10kb) Multiome | 1018 | |
| chr11:65,421,858–65,423,533 | 160.5 kb | Distal (>10kb) Multiome | 1197 | |
| chr11:65,454,735–65,455,360 | 193.3 kb | Distal (>10kb) Multiome | 573 | |
| chr11:65,477,100–65,477,990 | 215.7 kb | Distal (>10kb) Multiome | 991 | |
| chr11:65,487,451–65,488,490 | 225.9 kb | Distal (>10kb) Multiome | 706 | |
| chr11:65,496,515–65,498,726 | 235.7 kb | Distal (>10kb) Multiome | 1059 | |
| chr11:65,506,702–65,508,865 | 245.3 kb | Distal (>10kb) Multiome | 864 | |
| chr11:65,524,475–65,525,724 | 263.1 kb | Distal (>10kb) Multiome | 711 | |
| chr11:65,538,923–65,541,339 | 278.9 kb | Distal (>10kb) Multiome | 733 | |
| chr11:65,546,285–65,547,091 | 284.8 kb | Distal (>10kb) Multiome | 529 | |
| chr11:65,553,318–65,554,003 | 291.8 kb | Distal (>10kb) Multiome | 195 |
Genomic view of the POLA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.