The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Transcription factors with Perturb-seq knockdown data for POGZ. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POGZ upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POGZ, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:151,165,133–151,166,350 | 293.3 kb | Distal (>10kb) Multiome | 940 | |
| chr1:151,189,687–151,190,378 | 269.0 kb | Distal (>10kb) Multiome | 875 | |
| chr1:151,198,185–151,199,073 | 260.6 kb | Distal (>10kb) Multiome | 721 | |
| chr1:151,254,421–151,255,083 | 204.4 kb | Distal (>10kb) Multiome | 770 | |
| chr1:151,281,008–151,283,557 | 177.8 kb | Distal (>10kb) Multiome | 1121 | |
| chr1:151,327,019–151,328,343 | 131.5 kb | Distal (>10kb) Multiome | 719 | |
| chr1:151,346,796–151,347,793 | 111.9 kb | Distal (>10kb) Multiome | 711 | |
| chr1:151,399,359–151,400,043 | 59.6 kb | Distal (>10kb) Multiome | 776 | |
| chr1:151,458,247–151,459,879 | 276 bp | At TSS Multiome | 796 | |
| chr1:151,491,747–151,492,512 | 33.0 kb | Distal (>10kb) Multiome | 146 | |
| chr1:151,502,459–151,503,303 | 43.7 kb | Distal (>10kb) Multiome | 99 | |
| chr1:151,510,863–151,512,136 | 52.2 kb | Distal (>10kb) Multiome | 640 | |
| chr1:151,539,661–151,541,320 | 81.1 kb | Distal (>10kb) Multiome | 830 | |
| chr1:151,611,789–151,613,070 | 152.9 kb | Distal (>10kb) Multiome | 761 | |
| chr1:151,721,370–151,721,843 | 262.4 kb | Distal (>10kb) Multiome | 186 |
Genomic view of the POGZ locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.