This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for POGLUT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POGLUT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POGLUT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:102,591,759–102,592,780 | 206.8 kb | Distal (>10kb) Multiome HiCAR | 578 | |
| chr13:102,596,004–102,597,912 | 202.1 kb | Distal (>10kb) Multiome HiCAR | 918 | |
| chr13:102,772,804–102,774,609 | 25.2 kb | Distal (>10kb) Multiome | 683 | |
| chr13:102,793,671–102,794,261 | 4.7 kb | Proximal (<10kb) | 91 | |
| chr13:102,798,454–102,800,933 | 1.5 kb | Proximal (<10kb) Multiome | 954 | |
| chr13:102,845,306–102,846,942 | 46.9 kb | Distal (>10kb) Multiome | 1003 | |
| chr13:103,039,032–103,039,885 | 240.4 kb | Distal (>10kb) Multiome | 153 | |
| chr13:103,067,554–103,069,132 | 269.4 kb | Distal (>10kb) Multiome | 223 |
Genomic view of the POGLUT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.