This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a role in hematopoetic cell differentiation, and being expressed in vascular endothelium cells and binding to L-selectin. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PODXL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PODXL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PODXL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:131,327,222–131,328,641 | 228.8 kb | Distal (>10kb) Multiome | 963 | |
| chr7:131,513,393–131,514,233 | 42.9 kb | Distal (>10kb) Multiome | 446 | |
| chr7:131,546,665–131,547,151 | 9.8 kb | Proximal (<10kb) Multiome | 202 | |
| chr7:131,556,063–131,558,394 | 1.4 kb | Proximal (<10kb) Multiome | 671 | |
| chr7:131,604,843–131,605,922 | 48.8 kb | Distal (>10kb) Multiome HiCAR | 273 | |
| chr7:131,622,932–131,623,631 | 66.7 kb | Distal (>10kb) Multiome HiCAR | 194 | |
| chr7:131,625,703–131,626,457 | 69.5 kb | Distal (>10kb) Multiome HiCAR | 315 | |
| chr7:131,638,535–131,639,464 | 82.5 kb | Distal (>10kb) Multiome HiCAR | 84 | |
| chr7:131,648,307–131,649,602 | 92.5 kb | Distal (>10kb) Multiome HiCAR | 120 | |
| chr7:131,654,727–131,655,304 | 98.2 kb | Distal (>10kb) Multiome HiCAR | 306 | |
| chr7:131,691,912–131,692,612 | 135.6 kb | Distal (>10kb) Multiome | 352 | |
| chr7:131,792,989–131,793,733 | 236.8 kb | Distal (>10kb) Multiome | 42 | |
| chr7:131,795,009–131,795,742 | 238.7 kb | Distal (>10kb) Multiome | 57 | |
| chr7:131,829,569–131,830,504 | 273.4 kb | Distal (>10kb) Multiome | 132 |
Genomic view of the PODXL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.