This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]
Transcription factors with Perturb-seq knockdown data for PNPLA2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PNPLA2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PNPLA2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:534,525–536,399 | 283.3 kb | Distal (>10kb) Multiome | 673 | |
| chr11:536,654–537,918 | 281.5 kb | Distal (>10kb) Multiome | 558 | |
| chr11:554,380–556,321 | 263.8 kb | Distal (>10kb) Multiome | 460 | |
| chr11:559,830–562,079 | 258.1 kb | Distal (>10kb) Multiome | 791 | |
| chr11:567,850–569,533 | 250.3 kb | Distal (>10kb) Multiome | 672 | |
| chr11:574,830–576,748 | 242.8 kb | Distal (>10kb) Multiome | 793 | |
| chr11:613,334–614,059 | 205.2 kb | Distal (>10kb) Multiome | 215 | |
| chr11:615,262–616,320 | 203.0 kb | Distal (>10kb) Multiome | 443 | |
| chr11:636,786–637,700 | 181.8 kb | Distal (>10kb) Multiome | 161 | |
| chr11:693,835–696,330 | 123.5 kb | Distal (>10kb) Multiome | 873 | |
| chr11:705,737–706,270 | 112.9 kb | Distal (>10kb) Multiome | 361 | |
| chr11:720,619–721,074 | 98.0 kb | Distal (>10kb) Multiome | 156 | |
| chr11:727,901–728,499 | 90.7 kb | Distal (>10kb) Multiome | 686 | |
| chr11:746,704–748,069 | 71.6 kb | Distal (>10kb) Multiome | 755 | |
| chr11:762,582–763,602 | 55.6 kb | Distal (>10kb) Multiome | 326 | |
| chr11:776,216–778,328 | 41.5 kb | Distal (>10kb) Multiome | 770 | |
| chr11:783,385–783,909 | 35.2 kb | Distal (>10kb) Multiome | 278 | |
| chr11:797,112–798,675 | 20.7 kb | Distal (>10kb) Multiome | 697 | |
| chr11:804,241–805,812 | 13.6 kb | Distal (>10kb) Multiome | 725 | |
| chr11:808,894–810,402 | 9.2 kb | Proximal (<10kb) Multiome | 976 | |
| chr11:818,369–820,592 | 638 bp | At TSS Multiome | 749 | |
| chr11:826,980–828,116 | 8.6 kb | Proximal (<10kb) Multiome | 662 | |
| chr11:828,933–831,262 | 11.5 kb | Distal (>10kb) Multiome | 491 | |
| chr11:832,323–833,565 | 14.0 kb | Distal (>10kb) Multiome | 562 | |
| chr11:842,034–843,556 | 23.8 kb | Distal (>10kb) Multiome | 794 | |
| chr11:843,773–845,220 | 25.5 kb | Distal (>10kb) Multiome | 664 | |
| chr11:849,082–850,270 | 30.9 kb | Distal (>10kb) Multiome | 229 | |
| chr11:910,337–911,591 | 92.0 kb | Distal (>10kb) Multiome | 754 | |
| chr11:925,038–926,264 | 106.9 kb | Distal (>10kb) Multiome | 689 |
Genomic view of the PNPLA2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.