Predicted to enable semaphorin receptor activity. Predicted to be involved in several processes, including T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; nervous system development; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection extension; and regulation of smooth muscle cell migration. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLXNA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLXNA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLXNA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:126,654,554–126,655,321 | 327.6 kb | Distal (>10kb) Multiome HiCAR | 582 | |
| chr3:126,679,144–126,679,651 | 303.2 kb | Distal (>10kb) Multiome HiCAR | 342 | |
| chr3:126,703,722–126,704,881 | 278.6 kb | Distal (>10kb) Multiome HiCAR | 711 | |
| chr3:126,751,552–126,752,720 | 230.3 kb | Distal (>10kb) Multiome HiCAR | 361 | |
| chr3:126,887,820–126,888,945 | 94.3 kb | Distal (>10kb) Multiome | 92 | |
| chr3:126,933,925–126,934,641 | 48.3 kb | Distal (>10kb) Multiome HiCAR | 84 | |
| chr3:126,982,121–126,984,731 | 1.6 kb | Proximal (<10kb) Multiome | 876 | |
| chr3:127,002,021–127,002,655 | 19.6 kb | Distal (>10kb) Multiome | 261 | |
| chr3:127,209,659–127,210,613 | 227.4 kb | Distal (>10kb) Multiome | 89 | |
| chr3:127,455,528–127,456,092 | 473.0 kb | Distal (>10kb) Multiome HiCAR | 441 | |
| chr3:127,544,147–127,544,731 | 561.7 kb | Distal (>10kb) Multiome HiCAR | 252 | |
| chr3:127,547,261–127,548,296 | 565.2 kb | Distal (>10kb) Multiome HiCAR | 460 |
Genomic view of the PLXNA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.