Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. The protein encoded by this gene is a third distinct plastin isoform, which is specifically expressed at high levels in the small intestine. Alternatively spliced transcript variants varying in the 5' UTR, but encoding the same protein, have been found for this gene. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Feb 2010]
Transcription factors with Perturb-seq knockdown data for PLS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:142,447,330–142,448,346 | 148.4 kb | Distal (>10kb) Multiome | 859 | |
| chr3:142,568,423–142,569,093 | 27.8 kb | Distal (>10kb) Multiome | 163 | |
| chr3:142,578,301–142,579,268 | 17.6 kb | Distal (>10kb) Multiome | 1066 | |
| chr3:142,586,895–142,587,101 | 9.3 kb | Proximal (<10kb) | 253 | |
| chr3:142,595,928–142,596,960 | 47 bp | At TSS Multiome | 962 | |
| chr3:142,723,641–142,725,348 | 127.9 kb | Distal (>10kb) Multiome | 876 | |
| chr3:142,863,026–142,863,734 | 266.9 kb | Distal (>10kb) Multiome | 186 | |
| chr3:142,866,818–142,867,310 | 270.7 kb | Distal (>10kb) Multiome | 187 | |
| chr3:142,888,221–142,889,512 | 292.4 kb | Distal (>10kb) Multiome | 691 | |
| chr3:143,000,964–143,002,299 | 405.1 kb | Distal (>10kb) Multiome HiCAR | 1014 |
Genomic view of the PLS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.