The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for PLPP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLPP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLPP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:55,337,950–55,338,809 | 1241.1 kb | Distal (>10kb) Multiome HiCAR | 141 | |
| chr1:56,396,583–56,397,516 | 182.7 kb | Distal (>10kb) Multiome HiCAR | 195 | |
| chr1:56,436,904–56,437,573 | 142.4 kb | Distal (>10kb) Multiome HiCAR | 405 | |
| chr1:56,453,155–56,454,023 | 126.0 kb | Distal (>10kb) Multiome HiCAR | 234 | |
| chr1:56,477,272–56,478,021 | 101.9 kb | Distal (>10kb) Multiome | 431 | |
| chr1:56,494,285–56,494,744 | 85.1 kb | Distal (>10kb) Multiome | 431 | |
| chr1:56,535,168–56,535,889 | 44.0 kb | Distal (>10kb) Multiome HiCAR | 257 | |
| chr1:56,550,028–56,550,687 | 29.2 kb | Distal (>10kb) Multiome | 164 | |
| chr1:56,577,020–56,577,756 | 2.3 kb | Proximal (<10kb) Multiome | 246 | |
| chr1:56,578,195–56,579,838 | 130 bp | At TSS Multiome | 784 | |
| chr1:56,644,694–56,646,370 | 65.8 kb | Distal (>10kb) Multiome | 601 | |
| chr1:56,811,001–56,811,706 | 231.9 kb | Distal (>10kb) Multiome | 234 | |
| chr1:56,818,824–56,820,020 | 239.9 kb | Distal (>10kb) Multiome | 480 | |
| chr1:56,820,922–56,821,884 | 241.8 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the PLPP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.