This gene encodes a pyridoxal 5'-phosphate binding protein involved in the homeostatic regulation of intracellular pyridoxal 5'-phosphate. This gene has a tumor suppressive effect on hepatocellular carcinoma and other solid tumors of epithelial origin. Naturally occurring mutations in this gene are associated with a pyridoxine-dependent epilepsy. [provided by RefSeq, Mar 2017]
Transcription factors with Perturb-seq knockdown data for PLPBP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLPBP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLPBP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:37,675,185–37,675,906 | 87.2 kb | Distal (>10kb) Multiome | 507 | |
| chr8:37,694,827–37,698,811 | 67.1 kb | Distal (>10kb) Multiome | 830 | |
| chr8:37,735,982–37,737,291 | 26.1 kb | Distal (>10kb) Multiome | 958 | |
| chr8:37,762,144–37,763,270 | 83 bp | At TSS Multiome | 889 | |
| chr8:37,796,327–37,797,580 | 34.2 kb | Distal (>10kb) Multiome | 485 | |
| chr8:37,801,462–37,802,090 | 39.2 kb | Distal (>10kb) Multiome | 164 | |
| chr8:37,821,399–37,822,221 | 59.2 kb | Distal (>10kb) Multiome | 284 | |
| chr8:37,826,056–37,826,968 | 64.0 kb | Distal (>10kb) Multiome | 259 | |
| chr8:37,849,554–37,850,089 | 87.3 kb | Distal (>10kb) Multiome | 929 | |
| chr8:37,898,759–37,900,024 | 136.9 kb | Distal (>10kb) Multiome | 956 | |
| chr8:37,915,980–37,916,519 | 153.7 kb | Distal (>10kb) Multiome | 465 | |
| chr8:37,965,216–37,966,371 | 203.0 kb | Distal (>10kb) Multiome | 177 | |
| chr8:38,015,136–38,015,926 | 252.9 kb | Distal (>10kb) Multiome | 59 | |
| chr8:38,029,913–38,031,249 | 267.8 kb | Distal (>10kb) Multiome | 948 |
Genomic view of the PLPBP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.