This gene encodes a transmembrane proteolipid protein that is the predominant component of myelin. The encoded protein may play a role in the compaction, stabilization, and maintenance of myelin sheaths, as well as in oligodendrocyte development and axonal survival. Mutations in this gene cause Pelizaeus-Merzbacher disease and spastic paraplegia type 2. Alternatively splicing results in multiple transcript variants, including the DM20 splice variant. [provided by RefSeq, Feb 2015]
Transcription factors with Perturb-seq knockdown data for PLP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,607,566–103,608,355 | 168.8 kb | Distal (>10kb) Multiome | 234 | |
| chrX:103,686,434–103,687,597 | 90.0 kb | Distal (>10kb) Multiome | 737 | |
| chrX:103,766,973–103,767,614 | 9.3 kb | Proximal (<10kb) | 82 | |
| chrX:103,831,529–103,832,547 | 55.2 kb | Distal (>10kb) Multiome | 250 | |
| chrX:103,918,585–103,919,659 | 142.3 kb | Distal (>10kb) Multiome | 303 |
Genomic view of the PLP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.