Predicted to be involved in macrophage apoptotic process. Predicted to be located in extracellular region and ficolin-1-rich granule lumen. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLEKHO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,634,613–64,635,221 | 207.1 kb | Distal (>10kb) Multiome | 309 | |
| chr15:64,699,707–64,700,384 | 141.8 kb | Distal (>10kb) Multiome | 205 | |
| chr15:64,702,680–64,704,073 | 138.7 kb | Distal (>10kb) Multiome | 747 | |
| chr15:64,774,780–64,776,025 | 66.3 kb | Distal (>10kb) Multiome | 323 | |
| chr15:64,776,175–64,776,789 | 65.3 kb | Distal (>10kb) Multiome | 105 | |
| chr15:64,807,123–64,808,403 | 34.0 kb | Distal (>10kb) Multiome | 248 | |
| chr15:64,808,791–64,809,297 | 32.8 kb | Distal (>10kb) Multiome | 89 | |
| chr15:64,809,806–64,810,371 | 31.8 kb | Distal (>10kb) Multiome | 298 | |
| chr15:64,825,130–64,826,273 | 16.1 kb | Distal (>10kb) Multiome | 784 | |
| chr15:64,835,684–64,836,044 | 5.9 kb | Proximal (<10kb) | 521 | |
| chr15:64,840,757–64,843,201 | 278 bp | At TSS Multiome | 732 | |
| chr15:64,893,790–64,894,635 | 52.3 kb | Distal (>10kb) Multiome | 506 | |
| chr15:64,905,276–64,905,958 | 63.7 kb | Distal (>10kb) Multiome | 362 | |
| chr15:64,911,481–64,912,188 | 69.9 kb | Distal (>10kb) Multiome | 308 | |
| chr15:64,989,345–64,990,371 | 148.0 kb | Distal (>10kb) Multiome | 859 | |
| chr15:65,028,915–65,029,974 | 187.7 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,049,359–65,049,794 | 207.6 kb | Distal (>10kb) Multiome | 267 | |
| chr15:65,067,081–65,068,384 | 226.2 kb | Distal (>10kb) Multiome | 131 | |
| chr15:65,101,638–65,102,425 | 260.1 kb | Distal (>10kb) Multiome | 204 | |
| chr15:65,132,889–65,133,960 | 291.7 kb | Distal (>10kb) Multiome | 775 |
Genomic view of the PLEKHO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.