PLEKHG5

pleckstrin homology and RhoGEF domain containing G5 | ARHGEF45, GEF720, KIAA0720, Syx, Tech

This gene encodes a protein that activates the nuclear factor kappa B (NFKB1) signaling pathway. Mutations in this gene are associated with autosomal recessive distal spinal muscular atrophy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Member of: DE-5 Developmental clusters: GC6

Biological processes 21 terms

anchoring junction (GO:0070161)angiogenesis (GO:0001525)cell-cell junction (GO:0005911)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)endocytic vesicle (GO:0030139)endocytic vesicle (GO:0030139)endothelial cell chemotaxis (GO:0035767)endothelial cell migration (GO:0043542)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)guanyl-nucleotide exchange factor activity (GO:0005085)lamellipodium (GO:0030027)lamellipodium (GO:0030027)perinuclear region of cytoplasm (GO:0048471)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of canonical NF-kappaB signal transduction (GO:0043123)protein binding (GO:0005515)regulation of small GTPase mediated signal transduction (GO:0051056)

Expression (TPM)

TFs regulating PLEKHG5 0 TFs

Transcription factors with Perturb-seq knockdown data for PLEKHG5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHG5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PLEKHG5

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHG5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:6,199,148–6,200,364	297.7 kb	Distal (>10kb) Multiome	992
chr1:6,204,893–6,206,690	292.2 kb	Distal (>10kb) Multiome	913
chr1:6,208,737–6,209,635	288.1 kb	Distal (>10kb) Multiome	362
chr1:6,235,160–6,236,710	261.4 kb	Distal (>10kb) Multiome	673
chr1:6,241,773–6,242,771	255.2 kb	Distal (>10kb) Multiome	241
chr1:6,244,532–6,247,144	251.4 kb	Distal (>10kb) Multiome	1073
chr1:6,248,779–6,250,153	247.9 kb	Distal (>10kb) Multiome	287
chr1:6,259,688–6,261,954	237.3 kb	Distal (>10kb) Multiome	550
chr1:6,392,724–6,394,325	103.8 kb	Distal (>10kb) Multiome	819
chr1:6,418,998–6,420,339	77.6 kb	Distal (>10kb) Multiome	335
chr1:6,440,165–6,441,114	56.8 kb	Distal (>10kb) Multiome	215
chr1:6,446,981–6,449,427	50.3 kb	Distal (>10kb) Multiome	665
chr1:6,455,053–6,455,773	42.1 kb	Distal (>10kb) Multiome	105
chr1:6,470,716–6,471,189	26.5 kb	Distal (>10kb) Multiome	148
chr1:6,471,308–6,471,972	25.8 kb	Distal (>10kb) Multiome	192
chr1:6,475,592–6,475,800	9.7 kb	Proximal (<10kb)	288
chr1:6,484,959–6,485,762	at TSS	At TSS	144
chr1:6,486,194–6,486,953	10.8 kb	Distal (>10kb) Multiome	416
chr1:6,489,772–6,491,050	7.3 kb	Proximal (<10kb) Multiome	676
chr1:6,497,162–6,497,841	96 bp	At TSS Multiome	324
chr1:6,554,053–6,554,774	57.1 kb	Distal (>10kb) Multiome	897
chr1:6,579,406–6,580,453	82.5 kb	Distal (>10kb) Multiome	684
chr1:6,601,460–6,604,144	105.5 kb	Distal (>10kb) Multiome	1062
chr1:6,612,539–6,615,225	116.1 kb	Distal (>10kb) Multiome	806
chr1:6,624,591–6,625,845	127.8 kb	Distal (>10kb) Multiome	730
chr1:6,701,304–6,702,223	204.5 kb	Distal (>10kb) Multiome	1025
chr1:6,784,205–6,786,365	287.7 kb	Distal (>10kb) Multiome	950

Genome Browser

Genomic view of the PLEKHG5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.