Transcription factors with Perturb-seq knockdown data for PLEKHA6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLEKHA6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLEKHA6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:203,996,153–203,997,412 | 381.3 kb | Distal (>10kb) Multiome | 210 | |
| chr1:204,065,124–204,065,934 | 312.7 kb | Distal (>10kb) Multiome | 155 | |
| chr1:204,072,301–204,075,400 | 305.1 kb | Distal (>10kb) Multiome | 828 | |
| chr1:204,078,065–204,078,999 | 299.7 kb | Distal (>10kb) Multiome | 348 | |
| chr1:204,079,587–204,080,941 | 297.7 kb | Distal (>10kb) Multiome | 492 | |
| chr1:204,084,225–204,084,936 | 293.6 kb | Distal (>10kb) Multiome | 439 | |
| chr1:204,108,483–204,109,315 | 269.3 kb | Distal (>10kb) Multiome | 151 | |
| chr1:204,128,928–204,129,568 | 249.0 kb | Distal (>10kb) Multiome | 440 | |
| chr1:204,151,279–204,152,703 | 226.1 kb | Distal (>10kb) Multiome | 556 | |
| chr1:204,213,764–204,214,668 | 164.0 kb | Distal (>10kb) Multiome HiCAR | 702 | |
| chr1:204,287,567–204,288,449 | 90.1 kb | Distal (>10kb) Multiome | 373 | |
| chr1:204,289,294–204,289,779 | 88.7 kb | Distal (>10kb) Multiome | 126 | |
| chr1:204,304,190–204,304,358 | 3.0 kb | Proximal (<10kb) | 69 | |
| chr1:204,307,577–204,307,805 | 182 bp | At TSS | 181 | |
| chr1:204,317,215–204,317,471 | 9.8 kb | Proximal (<10kb) | 84 | |
| chr1:204,350,954–204,351,460 | 27.0 kb | Distal (>10kb) Multiome HiCAR | 138 | |
| chr1:204,363,217–204,363,961 | 14.5 kb | Distal (>10kb) Multiome HiCAR | 524 | |
| chr1:204,377,771–204,378,537 | 80 bp | At TSS Multiome | 593 | |
| chr1:204,411,136–204,412,704 | 33.7 kb | Distal (>10kb) Multiome | 939 | |
| chr1:204,417,015–204,417,887 | 39.3 kb | Distal (>10kb) Multiome | 590 | |
| chr1:204,446,280–204,446,835 | 68.3 kb | Distal (>10kb) Multiome | 311 | |
| chr1:204,493,614–204,495,352 | 116.5 kb | Distal (>10kb) Multiome | 876 | |
| chr1:204,506,146–204,507,240 | 128.3 kb | Distal (>10kb) Multiome | 889 | |
| chr1:204,507,371–204,508,288 | 129.8 kb | Distal (>10kb) Multiome | 508 | |
| chr1:204,515,995–204,516,830 | 138.2 kb | Distal (>10kb) Multiome | 1084 | |
| chr1:204,565,653–204,566,244 | 187.7 kb | Distal (>10kb) Multiome | 403 |
Genomic view of the PLEKHA6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.