This gene encodes a secreted serine protease that converts plasminogen to plasmin. The encoded preproprotein is proteolytically processed to generate A and B polypeptide chains. These chains associate via a single disulfide bond to form the catalytically inactive high molecular weight urokinase-type plasminogen activator (HMW-uPA). HMW-uPA can be further processed into the catalytically active low molecular weight urokinase-type plasminogen activator (LMW-uPA). This low molecular weight form does not bind to the urokinase-type plasminogen activator receptor. Mutations in this gene may be associated with Quebec platelet disorder and late-onset Alzheimer's disease. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for PLAU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:73,625,111–73,626,369 | 285.2 kb | Distal (>10kb) Multiome | 810 | |
| chr10:73,647,157–73,648,042 | 263.6 kb | Distal (>10kb) Multiome | 238 | |
| chr10:73,730,165–73,730,854 | 180.6 kb | Distal (>10kb) Multiome | 823 | |
| chr10:73,741,689–73,742,673 | 169.0 kb | Distal (>10kb) Multiome | 190 | |
| chr10:73,743,801–73,744,894 | 166.8 kb | Distal (>10kb) Multiome | 962 | |
| chr10:73,771,782–73,773,237 | 138.4 kb | Distal (>10kb) Multiome | 918 | |
| chr10:73,781,688–73,782,352 | 129.1 kb | Distal (>10kb) Multiome | 721 | |
| chr10:73,785,180–73,785,869 | 125.7 kb | Distal (>10kb) Multiome | 745 | |
| chr10:73,810,828–73,812,285 | 99.3 kb | Distal (>10kb) Multiome | 876 | |
| chr10:73,817,045–73,817,772 | 93.8 kb | Distal (>10kb) Multiome | 123 | |
| chr10:73,823,062–73,824,101 | 87.6 kb | Distal (>10kb) Multiome | 130 | |
| chr10:73,873,847–73,875,246 | 36.5 kb | Distal (>10kb) Multiome | 654 | |
| chr10:73,906,669–73,907,201 | 4.3 kb | Proximal (<10kb) Multiome | 417 | |
| chr10:73,910,388–73,911,812 | 51 bp | At TSS Multiome | 486 | |
| chr10:73,965,730–73,966,725 | 55.1 kb | Distal (>10kb) Multiome | 552 | |
| chr10:73,994,650–73,995,392 | 84.0 kb | Distal (>10kb) Multiome | 69 | |
| chr10:73,997,294–73,999,626 | 86.8 kb | Distal (>10kb) Multiome | 964 | |
| chr10:74,150,306–74,151,881 | 240.0 kb | Distal (>10kb) Multiome | 926 | |
| chr10:74,176,195–74,177,295 | 265.5 kb | Distal (>10kb) Multiome | 1072 | |
| chr10:75,079,403–75,080,508 | 1168.7 kb | Distal (>10kb) Multiome HiCAR | 189 |
Genomic view of the PLAU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.