Enables N-acyltransferase activity; phospholipase A1 activity; and phospholipase A2 activity. Acts upstream of or within N-acylphosphatidylethanolamine metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PLAAT5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAAT5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAAT5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:63,489,897–63,491,487 | 161 bp | At TSS Multiome | 254 | |
| chr11:63,491,633–63,492,303 | 810 bp | At TSS Multiome | 264 | |
| chr11:63,503,095–63,503,560 | 12.1 kb | Distal (>10kb) Multiome | 72 | |
| chr11:63,613,506–63,614,656 | 123.2 kb | Distal (>10kb) Multiome | 502 | |
| chr11:63,670,776–63,672,118 | 180.5 kb | Distal (>10kb) Multiome | 715 | |
| chr11:63,680,920–63,682,270 | 190.3 kb | Distal (>10kb) Multiome | 869 | |
| chr11:63,761,764–63,765,204 | 273.0 kb | Distal (>10kb) Multiome | 463 | |
| chr11:63,767,471–63,769,982 | 276.4 kb | Distal (>10kb) Multiome | 627 |
Genomic view of the PLAAT5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.