This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Sep 2010]
Transcription factors with Perturb-seq knockdown data for PLA2R1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLA2R1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLA2R1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:159,797,654–159,798,386 | 264.5 kb | Distal (>10kb) Multiome | 794 | |
| chr2:159,903,833–159,905,297 | 157.8 kb | Distal (>10kb) Multiome | 416 | |
| chr2:159,921,615–159,922,304 | 140.6 kb | Distal (>10kb) Multiome | 433 | |
| chr2:160,055,475–160,055,974 | 6.6 kb | Proximal (<10kb) | 86 | |
| chr2:160,061,841–160,063,521 | 88 bp | At TSS Multiome | 353 | |
| chr2:160,202,276–160,203,083 | 140.1 kb | Distal (>10kb) Multiome | 73 | |
| chr2:160,208,176–160,209,127 | 146.0 kb | Distal (>10kb) Multiome | 355 | |
| chr2:160,269,466–160,271,913 | 207.6 kb | Distal (>10kb) Multiome | 937 |
Genomic view of the PLA2R1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.