The protein encoded by this gene is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only three of them have been determined to date. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for PLA2G6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLA2G6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLA2G6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:37,905,849–37,906,846 | 275.6 kb | Distal (>10kb) Multiome | 552 | |
| chr22:37,933,777–37,934,256 | 247.8 kb | Distal (>10kb) Multiome | 679 | |
| chr22:37,953,153–37,954,120 | 228.2 kb | Distal (>10kb) Multiome | 617 | |
| chr22:37,983,021–37,985,110 | 197.4 kb | Distal (>10kb) Multiome | 228 | |
| chr22:38,052,312–38,052,803 | 129.4 kb | Distal (>10kb) Multiome | 529 | |
| chr22:38,057,008–38,057,702 | 124.6 kb | Distal (>10kb) Multiome | 656 | |
| chr22:38,080,912–38,081,618 | 100.7 kb | Distal (>10kb) Multiome | 175 | |
| chr22:38,097,697–38,098,236 | 83.9 kb | Distal (>10kb) Multiome | 186 | |
| chr22:38,180,914–38,181,242 | 625 bp | At TSS | 399 | |
| chr22:38,181,365–38,182,291 | 50 bp | At TSS Multiome | 676 | |
| chr22:38,201,378–38,203,636 | 20.0 kb | Distal (>10kb) Multiome | 848 | |
| chr22:38,207,844–38,208,187 | 6.6 kb | Proximal (<10kb) | 17 | |
| chr22:38,214,397–38,215,017 | 32.9 kb | Distal (>10kb) Multiome | 382 | |
| chr22:38,272,379–38,273,237 | 91.1 kb | Distal (>10kb) Multiome | 526 | |
| chr22:38,317,171–38,317,940 | 135.5 kb | Distal (>10kb) Multiome | 524 | |
| chr22:38,319,024–38,319,874 | 137.7 kb | Distal (>10kb) Multiome | 181 | |
| chr22:38,335,940–38,336,726 | 154.4 kb | Distal (>10kb) Multiome | 297 | |
| chr22:38,353,217–38,354,166 | 171.6 kb | Distal (>10kb) Multiome | 404 | |
| chr22:38,397,757–38,399,352 | 217.1 kb | Distal (>10kb) Multiome | 345 | |
| chr22:38,455,555–38,456,345 | 274.2 kb | Distal (>10kb) Multiome | 403 | |
| chr22:38,461,291–38,461,848 | 279.8 kb | Distal (>10kb) Multiome | 595 | |
| chr22:38,505,466–38,506,961 | 324.6 kb | Distal (>10kb) Multiome | 889 | |
| chr22:38,569,664–38,571,256 | 388.5 kb | Distal (>10kb) Multiome HiCAR | 559 |
Genomic view of the PLA2G6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.