This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for PLA2G3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLA2G3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLA2G3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,968,406–30,969,906 | 171.4 kb | Distal (>10kb) Multiome | 897 | |
| chr22:31,080,687–31,081,783 | 59.4 kb | Distal (>10kb) Multiome | 636 | |
| chr22:31,084,596–31,085,743 | 55.4 kb | Distal (>10kb) Multiome | 448 | |
| chr22:31,098,574–31,099,237 | 41.6 kb | Distal (>10kb) Multiome | 150 | |
| chr22:31,104,824–31,105,447 | 35.4 kb | Distal (>10kb) Multiome | 187 | |
| chr22:31,107,269–31,107,915 | 32.9 kb | Distal (>10kb) Multiome | 627 | |
| chr22:31,127,262–31,127,766 | 13.0 kb | Distal (>10kb) Multiome | 74 | |
| chr22:31,140,179–31,140,721 | 16 bp | At TSS Multiome | 244 | |
| chr22:31,149,054–31,149,291 | 8.5 kb | Proximal (<10kb) | 268 | |
| chr22:31,160,052–31,160,698 | 19.7 kb | Distal (>10kb) Multiome | 709 | |
| chr22:31,211,835–31,212,727 | 71.7 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,290,525–31,291,372 | 150.3 kb | Distal (>10kb) Multiome | 818 | |
| chr22:31,345,143–31,347,910 | 205.5 kb | Distal (>10kb) Multiome | 954 | |
| chr22:31,399,166–31,400,036 | 259.0 kb | Distal (>10kb) Multiome | 913 |
Genomic view of the PLA2G3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.