Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine to glycerophosphorylcholine and a free fatty acid. This enzyme is present in the plasma and thought to be associated with high-density lipoprotein. A later paper contradicts the function of this gene. It demonstrates that this gene encodes a lysosomal enzyme instead of a lysophospholipase and has both calcium-independent phospholipase A2 and transacylase activities. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PLA2G15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLA2G15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLA2G15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,963,746–67,964,209 | 281.4 kb | Distal (>10kb) Multiome | 161 | |
| chr16:67,968,087–67,969,341 | 276.7 kb | Distal (>10kb) Multiome | 861 | |
| chr16:67,993,130–67,993,736 | 251.9 kb | Distal (>10kb) Multiome | 790 | |
| chr16:68,019,222–68,020,043 | 225.9 kb | Distal (>10kb) Multiome | 108 | |
| chr16:68,022,490–68,023,556 | 222.2 kb | Distal (>10kb) Multiome | 958 | |
| chr16:68,084,205–68,086,133 | 160.1 kb | Distal (>10kb) Multiome | 1092 | |
| chr16:68,235,016–68,238,254 | 9.2 kb | Proximal (<10kb) Multiome | 1055 | |
| chr16:68,239,582–68,240,355 | 5.4 kb | Proximal (<10kb) Multiome | 223 | |
| chr16:68,244,730–68,245,757 | 101 bp | At TSS Multiome | 803 | |
| chr16:68,264,033–68,265,087 | 19.1 kb | Distal (>10kb) Multiome | 876 | |
| chr16:68,310,451–68,311,505 | 65.6 kb | Distal (>10kb) Multiome | 1061 | |
| chr16:68,328,654–68,329,423 | 83.4 kb | Distal (>10kb) Multiome HiCAR | 438 | |
| chr16:68,420,400–68,420,906 | 175.2 kb | Distal (>10kb) Multiome | 58 | |
| chr16:68,447,981–68,449,250 | 203.3 kb | Distal (>10kb) Multiome | 795 | |
| chr16:68,520,489–68,521,019 | 275.4 kb | Distal (>10kb) Multiome | 602 | |
| chr16:68,528,418–68,529,128 | 283.4 kb | Distal (>10kb) Multiome | 552 | |
| chr16:68,529,733–68,530,671 | 284.8 kb | Distal (>10kb) Multiome | 831 | |
| chr16:68,538,873–68,540,027 | 293.9 kb | Distal (>10kb) Multiome | 764 |
Genomic view of the PLA2G15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.