The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PKIA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PKIA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PKIA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:78,279,251–78,280,374 | 236.5 kb | Distal (>10kb) Multiome | 154 | |
| chr8:78,509,796–78,510,161 | 6.2 kb | Proximal (<10kb) | 99 | |
| chr8:78,511,351–78,511,683 | 4.7 kb | Proximal (<10kb) | 22 | |
| chr8:78,515,408–78,517,830 | 79 bp | At TSS Multiome | 678 | |
| chr8:78,665,297–78,666,867 | 149.7 kb | Distal (>10kb) Multiome | 823 | |
| chr8:78,804,276–78,805,655 | 288.4 kb | Distal (>10kb) Multiome | 746 |
Genomic view of the PKIA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.