Enables non-membrane spanning protein tyrosine kinase activity. Involved in peptidyl-tyrosine phosphorylation and skeletal system development. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PKDCC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PKDCC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PKDCC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:41,826,921–41,827,938 | 220.5 kb | Distal (>10kb) Multiome | 251 | |
| chr2:41,840,531–41,841,576 | 207.0 kb | Distal (>10kb) Multiome HiCAR | 820 | |
| chr2:41,937,467–41,937,918 | 110.4 kb | Distal (>10kb) Multiome HiCAR | 159 | |
| chr2:41,947,579–41,949,439 | 100.2 kb | Distal (>10kb) Multiome HiCAR | 291 | |
| chr2:41,992,220–41,993,306 | 55.2 kb | Distal (>10kb) Multiome | 188 | |
| chr2:42,036,200–42,036,946 | 11.4 kb | Distal (>10kb) Multiome | 103 | |
| chr2:42,040,785–42,040,962 | 7.1 kb | Proximal (<10kb) | 24 | |
| chr2:42,045,917–42,049,213 | 38 bp | At TSS Multiome | 846 | |
| chr2:42,051,093–42,052,337 | 3.1 kb | Proximal (<10kb) | 223 | |
| chr2:42,052,789–42,053,537 | 4.8 kb | Proximal (<10kb) | 182 | |
| chr2:42,054,639–42,055,081 | 6.6 kb | Proximal (<10kb) | 216 | |
| chr2:42,063,372–42,064,229 | 15.9 kb | Distal (>10kb) Multiome | 198 | |
| chr2:42,100,746–42,103,242 | 54.8 kb | Distal (>10kb) Multiome | 703 | |
| chr2:42,132,557–42,133,741 | 85.2 kb | Distal (>10kb) Multiome | 986 | |
| chr2:42,141,041–42,142,131 | 93.7 kb | Distal (>10kb) Multiome | 699 | |
| chr2:42,168,640–42,170,239 | 121.3 kb | Distal (>10kb) Multiome | 913 | |
| chr2:42,183,806–42,184,606 | 136.2 kb | Distal (>10kb) Multiome | 233 | |
| chr2:42,196,297–42,197,267 | 148.7 kb | Distal (>10kb) Multiome | 571 |
Genomic view of the PKDCC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.