The protein encoded by this gene is an ATP-dependent metalloprotease that degrades post-cleavage mitochondrial transit peptides. The encoded protein binds zinc and can also degrade amyloid beta A4 protein, suggesting a possible role in Alzheimer's disease. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for PITRM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PITRM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PITRM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:2,964,052–2,964,737 | 208.4 kb | Distal (>10kb) Multiome | 87 | |
| chr10:3,066,142–3,069,510 | 105.4 kb | Distal (>10kb) Multiome | 595 | |
| chr10:3,162,701–3,162,900 | 9.9 kb | Proximal (<10kb) | 32 | |
| chr10:3,172,061–3,174,070 | 265 bp | At TSS Multiome | 846 | |
| chr10:3,180,434–3,180,670 | 7.7 kb | Proximal (<10kb) | 28 | |
| chr10:3,197,197–3,197,909 | 24.7 kb | Distal (>10kb) Multiome | 553 | |
| chr10:3,332,842–3,333,930 | 160.7 kb | Distal (>10kb) Multiome | 150 | |
| chr10:4,825,541–4,827,059 | 1653.6 kb | Distal (>10kb) Multiome HiCAR | 564 |
Genomic view of the PITRM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.