The protein encoded by this gene catalyzes the conversion of phosphatidylserine to phosphatidylethanolamine in the inner mitochondrial membrane. The encoded protein is active in phospholipid metabolism and interorganelle trafficking of phosphatidylserine. [provided by RefSeq, May 2016]
Transcription factors with Perturb-seq knockdown data for PISD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PISD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PISD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:31,362,564–31,363,231 | 299.4 kb | Distal (>10kb) Multiome | 164 | |
| chr22:31,399,166–31,400,036 | 262.7 kb | Distal (>10kb) Multiome | 913 | |
| chr22:31,489,111–31,490,354 | 172.4 kb | Distal (>10kb) Multiome | 819 | |
| chr22:31,496,060–31,496,942 | 165.7 kb | Distal (>10kb) Multiome | 769 | |
| chr22:31,630,284–31,631,283 | 31.4 kb | Distal (>10kb) Multiome | 643 | |
| chr22:31,661,894–31,662,649 | 21 bp | At TSS Multiome | 791 | |
| chr22:31,665,712–31,665,919 | 3.5 kb | Proximal (<10kb) | 256 | |
| chr22:31,676,686–31,677,164 | 14.7 kb | Distal (>10kb) Multiome | 294 | |
| chr22:31,749,600–31,750,546 | 87.9 kb | Distal (>10kb) Multiome | 850 | |
| chr22:31,752,977–31,754,325 | 91.7 kb | Distal (>10kb) Multiome | 854 | |
| chr22:31,943,414–31,945,454 | 282.2 kb | Distal (>10kb) Multiome HiCAR | 807 | |
| chr22:31,969,969–31,971,124 | 308.4 kb | Distal (>10kb) Multiome HiCAR | 601 |
Genomic view of the PISD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.