PIP4K2B
phosphatidylinositol-5-phosphate 4-kinase type 2 beta | PIP5KIIB, PIP5KIIbeta, PIP5K2B

The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. [provided by RefSeq, Jul 2008]

Member of: DE-10 Developmental clusters: GC7 GC1
Biological processes 35 terms
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (GO:1902635)1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process (GO:1902635)1-phosphatidylinositol-4-phosphate 5-kinase activity (GO:0016308)1-phosphatidylinositol-4-phosphate 5-kinase activity (GO:0016308)1-phosphatidylinositol-5-phosphate 4-kinase activity (GO:0016309)1-phosphatidylinositol-5-phosphate 4-kinase activity (GO:0016309)ATP binding (GO:0005524)GTP binding (GO:0005525)autophagosome (GO:0005776)autophagosome (GO:0005776)autophagosome-lysosome fusion (GO:0061909)autophagosome-lysosome fusion (GO:0061909)cell surface receptor signaling pathway (GO:0007166)cytoplasm (GO:0005737)cytosol (GO:0005829)endoplasmic reticulum membrane (GO:0005789)negative regulation of insulin receptor signaling pathway (GO:0046627)negative regulation of insulin receptor signaling pathway (GO:0046627)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)phosphatidylinositol kinase activity (GO:0052742)phosphatidylinositol metabolic process (GO:0046488)phosphatidylinositol phosphate biosynthetic process (GO:0046854)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of autophagosome assembly (GO:2000786)positive regulation of autophagosome assembly (GO:2000786)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)regulation of autophagy (GO:0010506)regulation of autophagy (GO:0010506)regulation of autophagy (GO:0010506)
Expression (TPM)
PIP4K2B — as a Regulated Gene

TFs regulating PIP4K2B 0 TFs

Transcription factors with Perturb-seq knockdown data for PIP4K2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIP4K2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PIP4K2B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIP4K2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr17:38,509,961–38,510,926 289.0 kb Distal (>10kb) Multiome 409
chr17:38,558,106–38,558,652 241.2 kb Distal (>10kb) Multiome 631
chr17:38,559,205–38,559,900 239.9 kb Distal (>10kb) Multiome 598
chr17:38,572,553–38,573,232 226.5 kb Distal (>10kb) Multiome 231
chr17:38,604,448–38,605,250 194.6 kb Distal (>10kb) Multiome 375
chr17:38,605,359–38,606,888 193.0 kb Distal (>10kb) Multiome 781
chr17:38,609,172–38,610,061 189.9 kb Distal (>10kb) Multiome 229
chr17:38,673,658–38,675,315 124.5 kb Distal (>10kb) Multiome 847
chr17:38,701,857–38,703,072 97.1 kb Distal (>10kb) Multiome 907
chr17:38,703,568–38,704,668 95.5 kb Distal (>10kb) Multiome 955
chr17:38,704,725–38,707,220 94.1 kb Distal (>10kb) Multiome 784
chr17:38,718,492–38,719,127 80.8 kb Distal (>10kb) Multiome 268
chr17:38,719,228–38,720,635 79.3 kb Distal (>10kb) Multiome 290
chr17:38,729,824–38,730,713 69.3 kb Distal (>10kb) Multiome 794
chr17:38,747,498–38,750,334 49.7 kb Distal (>10kb) Multiome 914
chr17:38,751,747–38,753,201 47.8 kb Distal (>10kb) Multiome 986
chr17:38,789,155–38,789,604 10.1 kb Distal (>10kb) Multiome 144
chr17:38,798,912–38,800,293 406 bp At TSS Multiome 966
chr17:38,824,673–38,825,720 25.8 kb Distal (>10kb) Multiome 978
chr17:38,853,382–38,854,144 54.2 kb Distal (>10kb) Multiome 1047
chr17:38,867,391–38,868,381 68.2 kb Distal (>10kb) Multiome 640
chr17:38,869,253–38,871,194 70.3 kb Distal (>10kb) Multiome 1074
chr17:38,900,769–38,901,637 101.8 kb Distal (>10kb) Multiome 370
chr17:38,967,321–38,967,861 168.0 kb Distal (>10kb) Multiome 219
chr17:39,011,896–39,012,455 212.6 kb Distal (>10kb) Multiome 81
chr17:39,056,695–39,057,296 257.5 kb Distal (>10kb) Multiome 468

Genome Browser

Genomic view of the PIP4K2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr17:38,499,961 – 39,067,296
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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