PIK3R2
phosphoinositide-3-kinase regulatory subunit 2 | P85B, p85, p85-BETA, p85beta

Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Three transcript variants, one protein coding and the other two non-protein coding, have been found for this gene. [provided by RefSeq, Apr 2019]

Developmental clusters: GC1
Biological processes 36 terms
1-phosphatidylinositol-3-kinase regulator activity (GO:0046935)B cell differentiation (GO:0030183)T cell differentiation (GO:0030217)cellular response to insulin stimulus (GO:0032869)cellular response to insulin stimulus (GO:0032869)cytosol (GO:0005829)cytosol (GO:0005829)focal adhesion (GO:0005925)immune response (GO:0006955)insulin receptor signaling pathway (GO:0008286)insulin receptor signaling pathway (GO:0008286)intracellular glucose homeostasis (GO:0001678)intracellular glucose homeostasis (GO:0001678)negative regulation of MAPK cascade (GO:0043409)nucleus (GO:0005634)nucleus (GO:0005634)phosphatidylinositol 3-kinase complex, class IA (GO:0005943)phosphatidylinositol 3-kinase complex, class IA (GO:0005943)phosphatidylinositol 3-kinase regulatory subunit binding (GO:0036312)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphotyrosine residue binding (GO:0001784)phosphotyrosine residue binding (GO:0001784)positive regulation of protein import into nucleus (GO:0042307)positive regulation of protein import into nucleus (GO:0042307)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein phosphatase binding (GO:0019903)protein phosphatase binding (GO:0019903)receptor tyrosine kinase binding (GO:0030971)regulation of autophagy (GO:0010506)response to endoplasmic reticulum stress (GO:0034976)response to endoplasmic reticulum stress (GO:0034976)signal transduction (GO:0007165)
Expression (TPM)
PIK3R2 — as a Regulated Gene

TFs regulating PIK3R2 0 TFs

Transcription factors with Perturb-seq knockdown data for PIK3R2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3R2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to PIK3R2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3R2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:17,859,472–17,860,202 293.4 kb Distal (>10kb) Multiome 822
chr19:17,873,769–17,874,763 278.9 kb Distal (>10kb) Multiome 303
chr19:17,931,700–17,932,248 221.3 kb Distal (>10kb) Multiome 136
chr19:17,932,373–17,933,607 220.4 kb Distal (>10kb) Multiome 924
chr19:17,942,639–17,943,673 209.8 kb Distal (>10kb) Multiome 302
chr19:17,947,203–17,950,613 205.1 kb Distal (>10kb) Multiome 639
chr19:17,951,201–17,952,652 200.9 kb Distal (>10kb) Multiome 237
chr19:17,966,756–17,967,353 186.1 kb Distal (>10kb) Multiome 127
chr19:18,000,754–18,001,614 152.0 kb Distal (>10kb) Multiome 788
chr19:18,007,024–18,008,451 145.0 kb Distal (>10kb) Multiome 681
chr19:18,058,070–18,058,878 94.7 kb Distal (>10kb) Multiome 542
chr19:18,104,219–18,104,847 48.6 kb Distal (>10kb) Multiome 466
chr19:18,109,636–18,110,594 43.1 kb Distal (>10kb) Multiome 601
chr19:18,117,556–18,118,528 35.2 kb Distal (>10kb) Multiome 550
chr19:18,152,230–18,153,823 297 bp At TSS Multiome 809
chr19:18,153,931–18,154,340 769 bp At TSS 329
chr19:18,160,950–18,161,791 8.3 kb Proximal (<10kb) Multiome 494
chr19:18,173,513–18,174,441 20.6 kb Distal (>10kb) Multiome 667
chr19:18,192,530–18,193,908 39.9 kb Distal (>10kb) Multiome 758
chr19:18,202,796–18,205,452 51.1 kb Distal (>10kb) Multiome 823
chr19:18,220,660–18,221,487 67.8 kb Distal (>10kb) Multiome 134
chr19:18,223,665–18,226,306 70.9 kb Distal (>10kb) Multiome 790
chr19:18,232,737–18,233,413 80.0 kb Distal (>10kb) Multiome 789
chr19:18,278,462–18,282,788 128.6 kb Distal (>10kb) Multiome 1184
chr19:18,287,827–18,288,359 134.8 kb Distal (>10kb) Multiome 221
chr19:18,291,350–18,293,764 138.8 kb Distal (>10kb) Multiome 1026
chr19:18,322,635–18,323,493 170.1 kb Distal (>10kb) Multiome 814
chr19:18,328,417–18,328,936 175.4 kb Distal (>10kb) Multiome 488
chr19:18,339,807–18,340,160 186.8 kb Distal (>10kb) Multiome 249
chr19:18,340,428–18,341,393 187.4 kb Distal (>10kb) Multiome 747
chr19:18,373,917–18,374,961 221.4 kb Distal (>10kb) Multiome 971
chr19:18,388,239–18,388,884 235.4 kb Distal (>10kb) Multiome 910
chr19:18,416,224–18,418,189 263.5 kb Distal (>10kb) Multiome 893
chr19:18,418,296–18,420,432 266.3 kb Distal (>10kb) Multiome 773
chr19:18,428,554–18,429,777 276.0 kb Distal (>10kb) Multiome 489
chr19:18,433,114–18,434,328 281.0 kb Distal (>10kb) Multiome 446
chr19:18,436,634–18,439,166 284.1 kb Distal (>10kb) Multiome 799

Genome Browser

Genomic view of the PIK3R2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:17,849,472 – 18,449,166
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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