PIK3R1

PIK3R1

phosphoinositide-3-kinase regulatory subunit 1 | GRB1, p85, p85-ALPHA, p85alpha

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

Member of: DE-3 DE-3.37 Developmental clusters: GC6

Biological processes 92 terms

1-phosphatidylinositol-3-kinase regulator activity (GO:0046935)B cell differentiation (GO:0030183)ErbB-3 class receptor binding (GO:0043125)T cell differentiation (GO:0030217)T follicular helper cell differentiation (GO:0061470)cell-cell junction (GO:0005911)cellular response to insulin stimulus (GO:0032869)cellular response to insulin stimulus (GO:0032869)cellular response to insulin stimulus (GO:0032869)cis-Golgi network (GO:0005801)cytokine-mediated signaling pathway (GO:0019221)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)enzyme-substrate adaptor activity (GO:0140767)growth hormone receptor signaling pathway (GO:0060396)immune response (GO:0006955)insulin binding (GO:0043559)insulin receptor binding (GO:0005158)insulin receptor signaling pathway (GO:0008286)insulin receptor signaling pathway (GO:0008286)insulin receptor substrate binding (GO:0043560)insulin-like growth factor receptor binding (GO:0005159)insulin-like growth factor receptor signaling pathway (GO:0048009)insulin-like growth factor receptor signaling pathway (GO:0048009)insulin-like growth factor receptor signaling pathway (GO:0048009)interleukin-18-mediated signaling pathway (GO:0035655)intracellular glucose homeostasis (GO:0001678)intracellular glucose homeostasis (GO:0001678)kinase activator activity (GO:0019209)kinase regulator activity (GO:0019207)membrane (GO:0016020)membrane (GO:0016020)natural killer cell mediated cytotoxicity (GO:0042267)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)negative regulation of stress fiber assembly (GO:0051497)negative regulation of stress fiber assembly (GO:0051497)neurotrophin TRKA receptor binding (GO:0005168)nucleus (GO:0005634)nucleus (GO:0005634)perinuclear endoplasmic reticulum membrane (GO:1990578)perinuclear region of cytoplasm (GO:0048471)perinuclear region of cytoplasm (GO:0048471)phosphatidylinositol 3-kinase activator activity (GO:0141038)phosphatidylinositol 3-kinase binding (GO:0043548)phosphatidylinositol 3-kinase complex (GO:0005942)phosphatidylinositol 3-kinase complex, class IA (GO:0005943)phosphatidylinositol 3-kinase complex, class IA (GO:0005943)phosphatidylinositol 3-kinase complex, class IA (GO:0005943)phosphatidylinositol 3-kinase regulator activity (GO:0035014)phosphatidylinositol 3-kinase regulator activity (GO:0035014)phosphatidylinositol 3-kinase regulatory subunit binding (GO:0036312)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)phosphatidylinositol kinase activity (GO:0052742)phosphatidylinositol phosphate biosynthetic process (GO:0046854)phosphotyrosine residue binding (GO:0001784)phosphotyrosine residue binding (GO:0001784)plasma membrane (GO:0005886)positive regulation of D-glucose import across plasma membrane (GO:0046326)positive regulation of RNA splicing (GO:0033120)positive regulation of endoplasmic reticulum unfolded protein response (GO:1900103)positive regulation of filopodium assembly (GO:0051491)positive regulation of filopodium assembly (GO:0051491)positive regulation of focal adhesion disassembly (GO:0120183)positive regulation of focal adhesion disassembly (GO:0120183)positive regulation of lamellipodium assembly (GO:0010592)positive regulation of lamellipodium assembly (GO:0010592)positive regulation of protein import into nucleus (GO:0042307)positive regulation of protein import into nucleus (GO:0042307)positive regulation of protein localization to plasma membrane (GO:1903078)positive regulation of smooth muscle cell proliferation (GO:0048661)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein phosphatase binding (GO:0019903)protein phosphatase binding (GO:0019903)protein polyubiquitination (GO:0000209)protein stabilization (GO:0050821)regulation of toll-like receptor 4 signaling pathway (GO:0034143)response to endoplasmic reticulum stress (GO:0034976)response to endoplasmic reticulum stress (GO:0034976)response to endoplasmic reticulum stress (GO:0034976)signal transduction (GO:0007165)substrate adhesion-dependent cell spreading (GO:0034446)transmembrane receptor protein tyrosine kinase adaptor activity (GO:0005068)

Expression (TPM)

TFs regulating PIK3R1 0 TFs

Transcription factors with Perturb-seq knockdown data for PIK3R1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3R1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PIK3R1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3R1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr5:67,957,179–67,957,871	258.3 kb	Distal (>10kb) Multiome	259
	chr5:68,054,246–68,055,439	161.1 kb	Distal (>10kb) Multiome	168
	chr5:68,187,337–68,188,243	28.1 kb	Distal (>10kb) Multiome	245
	chr5:68,214,631–68,216,837	125 bp	At TSS Multiome	962
	chr5:68,287,871–68,289,169	72.7 kb	Distal (>10kb) Multiome	613
	chr5:68,353,260–68,354,829	138.1 kb	Distal (>10kb) Multiome	255
	chr5:68,436,487–68,437,544	221.1 kb	Distal (>10kb) Multiome	122
	chr5:68,922,292–68,922,890	706.8 kb	Distal (>10kb) Multiome HiCAR	63

Genome Browser

Genomic view of the PIK3R1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.