The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is sensitive to low nanomolar levels of the inhibitor wortmanin. The C2 domain of this protein was shown to bind phospholipids but not Ca2+, which suggests that this enzyme may function in a calcium-independent manner. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PIK3C2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIK3C2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIK3C2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:204,213,764–204,214,668 | 280.5 kb | Distal (>10kb) Multiome | 702 | |
| chr1:204,287,567–204,288,449 | 206.6 kb | Distal (>10kb) Multiome | 373 | |
| chr1:204,289,294–204,289,779 | 205.2 kb | Distal (>10kb) Multiome | 126 | |
| chr1:204,350,954–204,351,460 | 143.5 kb | Distal (>10kb) Multiome | 138 | |
| chr1:204,363,217–204,363,961 | 131.0 kb | Distal (>10kb) Multiome | 524 | |
| chr1:204,377,771–204,378,537 | 116.6 kb | Distal (>10kb) Multiome | 593 | |
| chr1:204,411,136–204,412,704 | 82.8 kb | Distal (>10kb) Multiome | 939 | |
| chr1:204,417,015–204,417,887 | 77.2 kb | Distal (>10kb) Multiome | 590 | |
| chr1:204,446,280–204,446,835 | 48.2 kb | Distal (>10kb) Multiome HiCAR | 311 | |
| chr1:204,493,614–204,495,352 | 17 bp | At TSS Multiome | 876 | |
| chr1:204,506,146–204,507,240 | 11.8 kb | Distal (>10kb) Multiome | 889 | |
| chr1:204,507,371–204,508,288 | 13.3 kb | Distal (>10kb) Multiome | 508 | |
| chr1:204,515,995–204,516,830 | 21.7 kb | Distal (>10kb) Multiome | 1084 | |
| chr1:204,565,653–204,566,244 | 71.2 kb | Distal (>10kb) Multiome | 403 | |
| chr1:204,684,550–204,685,936 | 190.8 kb | Distal (>10kb) Multiome | 313 | |
| chr1:204,709,678–204,711,587 | 215.8 kb | Distal (>10kb) Multiome | 521 | |
| chr1:204,714,466–204,715,865 | 220.3 kb | Distal (>10kb) Multiome | 356 |
Genomic view of the PIK3C2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.