The protein encoded by this gene is an inositol acyltransferase that acylates the inositol ring of phosphatidylinositol. This occurs in the endoplasmic reticulum and is a step in the biosynthesis of glycosylphosphatidylinositol (GPI), which anchors many cell surface proteins to the membrane. Defects in this gene are a cause of the age-dependent epileptic encephalopathy West syndrome as well as a syndrome exhibiting hyperphosphatasia and cognitive disability (HPMRS5). [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for PIGW. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGW upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGW, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:36,482,565–36,483,505 | 51.9 kb | Distal (>10kb) Multiome | 734 | |
| chr17:36,486,066–36,487,171 | 48.4 kb | Distal (>10kb) Multiome | 719 | |
| chr17:36,534,162–36,535,815 | 7 bp | At TSS Multiome | 1014 | |
| chr17:36,544,068–36,546,005 | 10.5 kb | Distal (>10kb) Multiome | 968 | |
| chr17:36,591,430–36,592,642 | 56.8 kb | Distal (>10kb) Multiome | 585 | |
| chr17:36,600,997–36,602,715 | 66.6 kb | Distal (>10kb) Multiome | 823 | |
| chr17:36,657,825–36,658,420 | 123.1 kb | Distal (>10kb) Multiome | 220 | |
| chr17:36,722,258–36,722,869 | 187.5 kb | Distal (>10kb) Multiome | 428 | |
| chr17:36,808,179–36,808,595 | 273.4 kb | Distal (>10kb) Multiome | 138 |
Genomic view of the PIGW locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.