The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Cdc91, a predicted integral membrane protein that may function in cell division control. The protein encoded by this gene is the fifth subunit of GPI transamidase that attaches GPI-anchors to proteins. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PIGU. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGU upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGU, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,515,293–34,516,855 | 161.6 kb | Distal (>10kb) Multiome | 1003 | |
| chr20:34,549,322–34,549,906 | 127.4 kb | Distal (>10kb) Multiome | 216 | |
| chr20:34,558,287–34,559,412 | 118.4 kb | Distal (>10kb) Multiome | 380 | |
| chr20:34,676,509–34,677,593 | 93 bp | At TSS Multiome | 954 | |
| chr20:34,703,810–34,705,103 | 27.4 kb | Distal (>10kb) Multiome | 903 | |
| chr20:34,708,877–34,710,404 | 32.7 kb | Distal (>10kb) Multiome | 576 | |
| chr20:34,824,452–34,825,860 | 148.4 kb | Distal (>10kb) Multiome | 852 | |
| chr20:34,872,384–34,873,259 | 195.8 kb | Distal (>10kb) Multiome | 817 | |
| chr20:34,874,110–34,874,535 | 197.2 kb | Distal (>10kb) Multiome | 357 | |
| chr20:34,875,878–34,877,081 | 199.3 kb | Distal (>10kb) Multiome | 852 | |
| chr20:34,955,039–34,956,224 | 278.7 kb | Distal (>10kb) Multiome | 1031 | |
| chr20:34,960,537–34,961,054 | 283.8 kb | Distal (>10kb) Multiome | 275 |
Genomic view of the PIGU locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.