This gene encodes an enzyme involved in the first step of glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells that serves to anchor proteins to the cell surface. The encoded protein is a component of the GPI-N-acetylglucosaminyltransferase complex that catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). This gene is located in the Down Syndrome critical region on chromosome 21 and is a candidate for the pathogenesis of Down syndrome. This gene has multiple pseudogenes and is a member of the phosphatidylinositol glycan anchor biosynthesis gene family. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016]
Transcription factors with Perturb-seq knockdown data for PIGP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:36,965,990–36,967,232 | 106.5 kb | Distal (>10kb) Multiome | 770 | |
| chr21:36,989,570–36,990,911 | 83.1 kb | Distal (>10kb) Multiome | 1026 | |
| chr21:37,006,026–37,007,215 | 66.6 kb | Distal (>10kb) Multiome | 280 | |
| chr21:37,041,546–37,042,235 | 31.2 kb | Distal (>10kb) Multiome | 119 | |
| chr21:37,072,329–37,074,488 | 94 bp | At TSS Multiome | 994 | |
| chr21:37,220,678–37,221,494 | 148.0 kb | Distal (>10kb) Multiome | 881 | |
| chr21:37,257,305–37,258,840 | 185.0 kb | Distal (>10kb) Multiome | 787 | |
| chr21:37,266,801–37,268,388 | 194.4 kb | Distal (>10kb) Multiome | 1079 | |
| chr21:37,365,724–37,368,330 | 293.3 kb | Distal (>10kb) Multiome | 938 |
Genomic view of the PIGP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.