PIGF

phosphatidylinositol glycan anchor biosynthesis class F | PIG-F

This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Member of: DE-7

Biological processes 11 terms

GPI anchor biosynthetic process (GO:0006506)GPI anchor biosynthetic process (GO:0006506)GPI anchor biosynthetic process (GO:0006506)GPI anchor biosynthetic process (GO:0006506)GPI anchor biosynthetic process (GO:0006506)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)endoplasmic reticulum membrane (GO:0005789)protein binding (GO:0005515)

Expression (TPM)

TFs regulating PIGF 0 TFs

Transcription factors with Perturb-seq knockdown data for PIGF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIGF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PIGF

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIGF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr2:46,499,830–46,500,537	116.8 kb	Distal (>10kb) Multiome	657
chr2:46,541,624–46,542,151	75.1 kb	Distal (>10kb) Multiome	610
chr2:46,542,212–46,544,274	74.5 kb	Distal (>10kb) Multiome	785
chr2:46,616,071–46,617,512	at TSS	At TSS Multiome	955
chr2:46,698,279–46,700,093	81.9 kb	Distal (>10kb) Multiome	974
chr2:46,704,551–46,705,027	87.8 kb	Distal (>10kb) Multiome	109
chr2:46,915,163–46,916,556	298.8 kb	Distal (>10kb) Multiome	931

Genome Browser

Genomic view of the PIGF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.