Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cilium; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PHLPP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHLPP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHLPP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:71,425,887–71,427,162 | 297.4 kb | Distal (>10kb) Multiome | 924 | |
| chr16:71,441,362–71,442,080 | 282.2 kb | Distal (>10kb) Multiome | 232 | |
| chr16:71,461,920–71,462,398 | 261.7 kb | Distal (>10kb) Multiome | 944 | |
| chr16:71,484,066–71,484,742 | 239.5 kb | Distal (>10kb) Multiome | 801 | |
| chr16:71,526,040–71,526,860 | 197.4 kb | Distal (>10kb) Multiome | 294 | |
| chr16:71,564,628–71,565,649 | 158.8 kb | Distal (>10kb) Multiome | 792 | |
| chr16:71,625,835–71,627,289 | 97.7 kb | Distal (>10kb) Multiome | 594 | |
| chr16:71,722,829–71,724,442 | 731 bp | At TSS Multiome | 894 | |
| chr16:71,808,251–71,809,603 | 85.3 kb | Distal (>10kb) Multiome | 1032 | |
| chr16:71,845,428–71,846,392 | 122.1 kb | Distal (>10kb) Multiome | 923 | |
| chr16:71,883,009–71,884,742 | 160.3 kb | Distal (>10kb) Multiome | 791 | |
| chr16:71,894,288–71,896,022 | 171.5 kb | Distal (>10kb) Multiome | 1139 | |
| chr16:71,981,752–71,982,390 | 258.2 kb | Distal (>10kb) Multiome | 263 | |
| chr16:72,008,426–72,009,172 | 284.8 kb | Distal (>10kb) Multiome | 815 | |
| chr16:72,013,585–72,014,228 | 290.2 kb | Distal (>10kb) Multiome | 263 |
Genomic view of the PHLPP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.