Predicted to enable zinc ion binding activity. Involved in negative regulation of autophagosome assembly; negative regulation of autophagosome maturation; and positive regulation of protein ubiquitination. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHF23. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHF23 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHF23, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:6,995,886–6,996,299 | 241.8 kb | Distal (>10kb) Multiome | 124 | |
| chr17:7,012,245–7,012,890 | 225.3 kb | Distal (>10kb) Multiome | 804 | |
| chr17:7,014,335–7,015,213 | 223.0 kb | Distal (>10kb) Multiome | 842 | |
| chr17:7,021,831–7,024,265 | 213.9 kb | Distal (>10kb) Multiome | 614 | |
| chr17:7,035,527–7,036,637 | 201.8 kb | Distal (>10kb) Multiome | 791 | |
| chr17:7,132,532–7,133,109 | 105.0 kb | Distal (>10kb) Multiome | 312 | |
| chr17:7,177,263–7,177,909 | 60.3 kb | Distal (>10kb) Multiome | 453 | |
| chr17:7,204,820–7,205,551 | 32.7 kb | Distal (>10kb) Multiome | 364 | |
| chr17:7,207,943–7,208,476 | 29.6 kb | Distal (>10kb) Multiome | 91 | |
| chr17:7,213,858–7,216,461 | 23.3 kb | Distal (>10kb) Multiome | 737 | |
| chr17:7,219,603–7,220,515 | 17.9 kb | Distal (>10kb) Multiome | 793 | |
| chr17:7,233,847–7,235,210 | 3.3 kb | Proximal (<10kb) Multiome | 1020 | |
| chr17:7,237,531–7,238,757 | 166 bp | At TSS Multiome | 502 | |
| chr17:7,238,867–7,240,155 | 1.9 kb | Proximal (<10kb) Multiome | 783 | |
| chr17:7,241,494–7,243,462 | 5.3 kb | Proximal (<10kb) Multiome | 1037 | |
| chr17:7,251,263–7,252,962 | 14.4 kb | Distal (>10kb) Multiome | 985 | |
| chr17:7,260,746–7,263,748 | 24.8 kb | Distal (>10kb) Multiome | 639 | |
| chr17:7,280,161–7,282,555 | 43.9 kb | Distal (>10kb) Multiome | 841 | |
| chr17:7,293,901–7,295,189 | 57.0 kb | Distal (>10kb) Multiome | 443 | |
| chr17:7,296,224–7,296,683 | 58.8 kb | Distal (>10kb) Multiome | 688 | |
| chr17:7,306,788–7,309,027 | 69.6 kb | Distal (>10kb) Multiome | 896 | |
| chr17:7,314,722–7,315,725 | 77.5 kb | Distal (>10kb) Multiome | 843 | |
| chr17:7,328,881–7,330,972 | 91.7 kb | Distal (>10kb) Multiome | 809 | |
| chr17:7,349,378–7,350,590 | 112.5 kb | Distal (>10kb) Multiome | 414 | |
| chr17:7,351,208–7,352,575 | 114.3 kb | Distal (>10kb) Multiome | 857 | |
| chr17:7,356,082–7,356,523 | 118.5 kb | Distal (>10kb) Multiome | 485 | |
| chr17:7,383,791–7,384,537 | 146.4 kb | Distal (>10kb) Multiome | 218 | |
| chr17:7,393,924–7,395,223 | 156.9 kb | Distal (>10kb) Multiome | 744 | |
| chr17:7,403,290–7,405,695 | 166.6 kb | Distal (>10kb) Multiome | 838 | |
| chr17:7,435,167–7,437,681 | 199.3 kb | Distal (>10kb) Multiome | 828 | |
| chr17:7,437,892–7,438,555 | 200.5 kb | Distal (>10kb) Multiome | 224 | |
| chr17:7,440,048–7,441,211 | 202.9 kb | Distal (>10kb) Multiome | 487 | |
| chr17:7,444,968–7,446,142 | 207.8 kb | Distal (>10kb) Multiome | 632 | |
| chr17:7,455,450–7,456,019 | 217.9 kb | Distal (>10kb) Multiome | 414 | |
| chr17:7,478,839–7,480,126 | 241.7 kb | Distal (>10kb) Multiome | 574 | |
| chr17:7,483,139–7,485,576 | 246.7 kb | Distal (>10kb) Multiome | 1156 |
Genomic view of the PHF23 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.