Enables methylation-dependent protein binding activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of NSL complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PHF20L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHF20L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHF20L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:132,479,879–132,481,822 | 294.2 kb | Distal (>10kb) Multiome | 326 | |
| chr8:132,589,830–132,590,792 | 185.1 kb | Distal (>10kb) Multiome | 70 | |
| chr8:132,625,357–132,625,870 | 149.7 kb | Distal (>10kb) Multiome | 24 | |
| chr8:132,674,976–132,676,125 | 99.8 kb | Distal (>10kb) Multiome | 678 | |
| chr8:132,768,637–132,768,781 | 6.6 kb | Proximal (<10kb) | 157 | |
| chr8:132,773,140–132,773,362 | 2.0 kb | Proximal (<10kb) | 76 | |
| chr8:132,774,781–132,775,966 | 5 bp | At TSS Multiome | 755 |
Genomic view of the PHF20L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.