This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PHF10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PHF10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PHF10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:169,619,312–169,620,680 | 104.1 kb | Distal (>10kb) Multiome | 164 | |
| chr6:169,654,626–169,655,354 | 69.7 kb | Distal (>10kb) Multiome | 165 | |
| chr6:169,656,289–169,657,223 | 67.8 kb | Distal (>10kb) Multiome | 87 | |
| chr6:169,701,339–169,702,982 | 22.4 kb | Distal (>10kb) Multiome | 1050 | |
| chr6:169,722,834–169,723,157 | 1.3 kb | Proximal (<10kb) | 460 | |
| chr6:169,723,431–169,725,573 | 107 bp | At TSS Multiome | 1078 | |
| chr6:169,751,101–169,752,286 | 27.2 kb | Distal (>10kb) Multiome | 1057 | |
| chr6:169,789,764–169,790,892 | 65.8 kb | Distal (>10kb) Multiome | 772 | |
| chr6:169,810,281–169,811,431 | 86.1 kb | Distal (>10kb) Multiome | 326 | |
| chr6:170,006,902–170,008,105 | 282.9 kb | Distal (>10kb) Multiome | 196 |
Genomic view of the PHF10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.