This gene encodes a putative membrane-associated progesterone steroid receptor. The protein is expressed predominantly in the liver and kidney. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for PGRMC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PGRMC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PGRMC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:119,007,145–119,007,885 | 228.8 kb | Distal (>10kb) Multiome | 49 | |
| chrX:119,235,776–119,237,022 | 40 bp | At TSS Multiome | 578 | |
| chrX:119,273,185–119,274,073 | 37.4 kb | Distal (>10kb) Multiome | 148 | |
| chrX:119,399,020–119,399,773 | 163.1 kb | Distal (>10kb) Multiome | 440 | |
| chrX:119,468,031–119,469,511 | 232.1 kb | Distal (>10kb) Multiome | 762 |
Genomic view of the PGRMC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.