PFDN6

prefoldin subunit 6 | H2-KE2, KE-2, PFD6, HKE2

PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]

Member of: DE-1

Biological processes 19 terms

amyloid-beta binding (GO:0001540)chaperone-mediated protein complex assembly (GO:0051131)chaperone-mediated protein complex assembly (GO:0051131)cytoplasm (GO:0005737)negative regulation of amyloid fibril formation (GO:1905907)prefoldin complex (GO:0016272)prefoldin complex (GO:0016272)prefoldin complex (GO:0016272)protein binding (GO:0005515)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein folding (GO:0006457)protein stabilization (GO:0050821)protein-folding chaperone binding (GO:0051087)protein-folding chaperone binding (GO:0051087)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)unfolded protein binding (GO:0051082)

Expression (TPM)

TFs regulating PFDN6 0 TFs

Transcription factors with Perturb-seq knockdown data for PFDN6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PFDN6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PFDN6

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PFDN6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:33,009,348–33,009,899	280.0 kb	Distal (>10kb) Multiome	184
chr6:33,080,635–33,081,087	209.0 kb	Distal (>10kb) Multiome	141
chr6:33,161,505–33,162,100	127.9 kb	Distal (>10kb) Multiome	589
chr6:33,199,801–33,201,289	89.0 kb	Distal (>10kb) Multiome	1049
chr6:33,204,263–33,205,422	85.0 kb	Distal (>10kb) Multiome	762
chr6:33,208,069–33,208,990	81.0 kb	Distal (>10kb) Multiome	858
chr6:33,248,132–33,249,983	41.4 kb	Distal (>10kb) Multiome	961
chr6:33,271,370–33,272,508	17.7 kb	Distal (>10kb) Multiome	1058
chr6:33,276,685–33,277,905	12.2 kb	Distal (>10kb) Multiome	807
chr6:33,280,035–33,280,319	9.3 kb	Proximal (<10kb)	342
chr6:33,288,941–33,289,881	231 bp	At TSS Multiome	701
chr6:33,297,445–33,300,232	8.2 kb	Proximal (<10kb) Multiome	1095
chr6:33,312,436–33,314,207	23.3 kb	Distal (>10kb) Multiome	795
chr6:33,317,189–33,318,504	28.3 kb	Distal (>10kb) Multiome	649
chr6:33,322,636–33,323,832	33.5 kb	Distal (>10kb) Multiome	941
chr6:33,346,609–33,347,126	57.2 kb	Distal (>10kb) Multiome	37
chr6:33,390,888–33,392,247	102.0 kb	Distal (>10kb) Multiome	993
chr6:33,409,936–33,411,502	120.9 kb	Distal (>10kb) Multiome	977
chr6:33,417,606–33,419,249	128.6 kb	Distal (>10kb) Multiome	973
chr6:33,419,793–33,420,532	130.6 kb	Distal (>10kb) Multiome	162
chr6:33,425,590–33,426,362	136.2 kb	Distal (>10kb) Multiome	665
chr6:33,431,024–33,432,096	141.6 kb	Distal (>10kb) Multiome	337
chr6:33,454,074–33,454,852	164.9 kb	Distal (>10kb) Multiome	906
chr6:33,547,185–33,548,324	258.1 kb	Distal (>10kb) Multiome	155
chr6:33,570,899–33,571,638	281.8 kb	Distal (>10kb) Multiome	755
chr6:33,579,935–33,580,700	290.7 kb	Distal (>10kb) Multiome	639

Genome Browser

Genomic view of the PFDN6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.