This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PFDN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PFDN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PFDN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:53,593,066–53,594,853 | 613.7 kb | Distal (>10kb) Multiome HiCAR | 756 | |
| chr20:53,915,176–53,916,090 | 292.3 kb | Distal (>10kb) Multiome | 707 | |
| chr20:53,918,946–53,919,429 | 289.0 kb | Distal (>10kb) Multiome | 208 | |
| chr20:53,938,349–53,940,222 | 268.0 kb | Distal (>10kb) Multiome | 696 | |
| chr20:53,942,064–53,942,654 | 265.8 kb | Distal (>10kb) Multiome | 226 | |
| chr20:54,172,603–54,174,432 | 34.0 kb | Distal (>10kb) Multiome | 608 | |
| chr20:54,199,741–54,199,941 | 8.1 kb | Proximal (<10kb) | 249 | |
| chr20:54,207,506–54,209,250 | 130 bp | At TSS Multiome | 1046 | |
| chr20:54,223,363–54,224,391 | 15.9 kb | Distal (>10kb) Multiome | 143 | |
| chr20:54,385,104–54,385,871 | 177.4 kb | Distal (>10kb) Multiome | 96 | |
| chr20:54,474,748–54,476,808 | 267.5 kb | Distal (>10kb) Multiome | 269 |
Genomic view of the PFDN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.