Mitochondrial complex IV, or cytochrome c oxidase, is a large transmembrane protein complex that is part of the respiratory electron transport chain of mitochondria. The small protein encoded by this gene plays a role in the biogenesis of mitochondrial complex IV. This protein localizes to the inner mitochondrial membrane and is exposed to the intermembrane space. Mutations in this gene are associated with mitochondrial complex IV deficiency. This gene has a pseudogene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Transcription factors with Perturb-seq knockdown data for PET100. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PET100 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PET100, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:7,394,774–7,395,629 | 234.7 kb | Distal (>10kb) Multiome | 601 | |
| chr19:7,482,657–7,483,489 | 146.6 kb | Distal (>10kb) Multiome | 201 | |
| chr19:7,488,712–7,489,463 | 140.7 kb | Distal (>10kb) Multiome | 542 | |
| chr19:7,500,843–7,501,401 | 128.6 kb | Distal (>10kb) Multiome | 556 | |
| chr19:7,505,850–7,507,270 | 123.3 kb | Distal (>10kb) Multiome | 516 | |
| chr19:7,507,812–7,508,356 | 121.7 kb | Distal (>10kb) Multiome | 168 | |
| chr19:7,522,263–7,523,208 | 107.2 kb | Distal (>10kb) Multiome | 917 | |
| chr19:7,533,976–7,536,472 | 95.8 kb | Distal (>10kb) Multiome | 882 | |
| chr19:7,550,673–7,551,762 | 78.4 kb | Distal (>10kb) Multiome | 377 | |
| chr19:7,554,651–7,555,821 | 74.5 kb | Distal (>10kb) Multiome | 224 | |
| chr19:7,595,485–7,596,417 | 34.0 kb | Distal (>10kb) Multiome | 405 | |
| chr19:7,629,285–7,629,891 | 108 bp | At TSS Multiome | 650 | |
| chr19:7,636,753–7,637,571 | 7.3 kb | Proximal (<10kb) Multiome | 689 | |
| chr19:7,680,480–7,681,546 | 51.0 kb | Distal (>10kb) Multiome | 679 | |
| chr19:7,829,238–7,830,666 | 200.1 kb | Distal (>10kb) Multiome | 621 | |
| chr19:7,853,168–7,853,781 | 223.7 kb | Distal (>10kb) Multiome | 747 | |
| chr19:7,861,607–7,864,383 | 232.9 kb | Distal (>10kb) Multiome | 348 | |
| chr19:7,868,454–7,870,252 | 239.7 kb | Distal (>10kb) Multiome | 721 | |
| chr19:7,871,072–7,872,772 | 242.3 kb | Distal (>10kb) Multiome | 487 | |
| chr19:7,873,962–7,875,061 | 244.8 kb | Distal (>10kb) Multiome | 416 | |
| chr19:7,888,334–7,888,798 | 258.7 kb | Distal (>10kb) Multiome | 509 | |
| chr19:7,902,730–7,904,931 | 274.0 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:7,917,358–7,918,182 | 288.1 kb | Distal (>10kb) Multiome | 316 | |
| chr19:7,919,934–7,921,640 | 290.9 kb | Distal (>10kb) Multiome | 802 | |
| chr19:7,924,612–7,926,698 | 295.5 kb | Distal (>10kb) Multiome | 766 |
Genomic view of the PET100 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.