This gene encodes a transcription factor which coactivates transcription of estrogen receptor responsive genes and corepresses genes activated by other hormone receptors or sequence-specific transcription factors. Expression of this gene is regulated by both members of the estrogen receptor family. This gene may be involved in the progression of several types of cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
Transcription factors with Perturb-seq knockdown data for PELP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PELP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PELP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:4,498,488–4,499,859 | 205.3 kb | Distal (>10kb) Multiome | 361 | |
| chr17:4,555,276–4,555,773 | 148.7 kb | Distal (>10kb) Multiome | 806 | |
| chr17:4,583,931–4,585,086 | 119.8 kb | Distal (>10kb) Multiome | 323 | |
| chr17:4,703,669–4,704,637 | 11 bp | At TSS Multiome | 854 | |
| chr17:4,708,553–4,709,232 | 4.6 kb | Proximal (<10kb) Multiome | 71 | |
| chr17:4,709,724–4,711,094 | 6.3 kb | Proximal (<10kb) Multiome | 771 | |
| chr17:4,730,794–4,732,115 | 27.4 kb | Distal (>10kb) Multiome | 936 | |
| chr17:4,745,124–4,745,511 | 41.3 kb | Distal (>10kb) Multiome | 67 | |
| chr17:4,789,618–4,790,520 | 86.1 kb | Distal (>10kb) Multiome | 816 | |
| chr17:4,795,974–4,796,433 | 92.0 kb | Distal (>10kb) Multiome | 751 | |
| chr17:4,806,693–4,807,619 | 102.9 kb | Distal (>10kb) Multiome | 494 | |
| chr17:4,832,863–4,833,956 | 129.2 kb | Distal (>10kb) Multiome | 730 | |
| chr17:4,898,962–4,900,112 | 195.3 kb | Distal (>10kb) Multiome | 257 | |
| chr17:4,900,249–4,901,057 | 196.7 kb | Distal (>10kb) Multiome | 145 | |
| chr17:4,909,117–4,909,538 | 205.1 kb | Distal (>10kb) Multiome | 553 | |
| chr17:4,939,475–4,941,034 | 236.0 kb | Distal (>10kb) Multiome | 821 | |
| chr17:4,947,426–4,950,636 | 246.0 kb | Distal (>10kb) Multiome | 1080 | |
| chr17:4,966,739–4,968,875 | 263.4 kb | Distal (>10kb) Multiome | 982 | |
| chr17:4,986,950–4,987,983 | 283.4 kb | Distal (>10kb) Multiome | 881 | |
| chr17:4,996,838–4,998,964 | 293.6 kb | Distal (>10kb) Multiome | 759 |
Genomic view of the PELP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.