Predicted to enable protein-macromolecule adaptor activity and ubiquitin protein ligase activity. Acts upstream of or within positive regulation of MAPK cascade and positive regulation of protein phosphorylation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PELI2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PELI2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PELI2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:55,730,593–55,731,050 | 387.6 kb | Distal (>10kb) Multiome HiCAR | 138 | |
| chr14:55,748,902–55,749,661 | 369.1 kb | Distal (>10kb) Multiome HiCAR | 180 | |
| chr14:55,864,862–55,865,309 | 253.2 kb | Distal (>10kb) Multiome | 147 | |
| chr14:55,931,852–55,932,352 | 186.3 kb | Distal (>10kb) Multiome | 25 | |
| chr14:56,117,712–56,119,538 | 185 bp | At TSS Multiome | 571 | |
| chr14:56,119,642–56,119,998 | 1.2 kb | Proximal (<10kb) | 115 |
Genomic view of the PELI2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.