PEA15

proliferation and apoptosis adaptor protein 15 | HMAT1, HUMMAT1H, MAT1, MAT1H, PEA-15, PED, PED-PEA15, PED/PEA15

This gene encodes a death effector domain-containing protein that functions as a negative regulator of apoptosis. The encoded protein is an endogenous substrate for protein kinase C. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Developmental clusters: GC4

Biological processes 11 terms

MAPK cascade (GO:0000165)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)microtubule associated complex (GO:0005875)negative regulation of D-glucose import across plasma membrane (GO:0046325)negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)protein binding (GO:0005515)regulation of apoptotic process (GO:0042981)

Expression (TPM)

TFs regulating PEA15 0 TFs

Transcription factors with Perturb-seq knockdown data for PEA15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PEA15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PEA15

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PEA15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:159,922,909–159,926,224	279.8 kb	Distal (>10kb) Multiome	922
chr1:159,929,315–159,930,329	275.6 kb	Distal (>10kb) Multiome	235
chr1:159,936,265–159,937,075	268.8 kb	Distal (>10kb) Multiome	355
chr1:159,945,025–159,946,368	259.6 kb	Distal (>10kb) Multiome	624
chr1:160,031,268–160,032,381	173.4 kb	Distal (>10kb) Multiome	780
chr1:160,046,290–160,047,082	158.6 kb	Distal (>10kb) Multiome	540
chr1:160,069,829–160,071,049	135.0 kb	Distal (>10kb) Multiome	419
chr1:160,083,809–160,084,575	121.1 kb	Distal (>10kb) Multiome	327
chr1:160,095,707–160,096,231	109.4 kb	Distal (>10kb) Multiome HiCAR	79
chr1:160,097,214–160,099,572	106.5 kb	Distal (>10kb) Multiome HiCAR	659
chr1:160,100,845–160,101,543	104.2 kb	Distal (>10kb) Multiome HiCAR	530
chr1:160,169,049–160,170,141	35.7 kb	Distal (>10kb) Multiome HiCAR	330
chr1:160,192,913–160,193,769	12.0 kb	Distal (>10kb) Multiome	551
chr1:160,204,860–160,206,035	12 bp	At TSS Multiome	637
chr1:160,261,515–160,263,143	57.1 kb	Distal (>10kb) Multiome	992
chr1:160,284,609–160,285,332	79.8 kb	Distal (>10kb) Multiome	638
chr1:160,342,945–160,343,700	137.9 kb	Distal (>10kb) Multiome	868
chr1:160,399,764–160,401,441	195.1 kb	Distal (>10kb) Multiome	590

Genome Browser

Genomic view of the PEA15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.