Predicted to enable lipid binding activity and zinc ion binding activity. Involved in several processes, including mitochondrial calcium ion homeostasis; mitochondrion-endoplasmic reticulum membrane tethering; and regulation of cell morphogenesis. Located in endoplasmic reticulum membrane and mitochondria-associated endoplasmic reticulum membrane contact site. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PDZD8. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDZD8 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDZD8, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:117,134,080–117,135,217 | 240.8 kb | Distal (>10kb) Multiome | 216 | |
| chr10:117,136,768–117,138,029 | 238.2 kb | Distal (>10kb) Multiome | 337 | |
| chr10:117,138,997–117,141,025 | 236.0 kb | Distal (>10kb) Multiome | 182 | |
| chr10:117,159,202–117,159,932 | 215.8 kb | Distal (>10kb) Multiome | 133 | |
| chr10:117,162,523–117,164,008 | 212.2 kb | Distal (>10kb) Multiome | 315 | |
| chr10:117,165,627–117,166,409 | 209.5 kb | Distal (>10kb) Multiome | 272 | |
| chr10:117,167,701–117,168,673 | 207.1 kb | Distal (>10kb) Multiome | 441 | |
| chr10:117,198,137–117,198,892 | 177.1 kb | Distal (>10kb) Multiome | 20 | |
| chr10:117,216,481–117,217,759 | 158.6 kb | Distal (>10kb) Multiome | 688 | |
| chr10:117,240,160–117,242,055 | 134.4 kb | Distal (>10kb) Multiome | 361 | |
| chr10:117,346,576–117,347,199 | 28.6 kb | Distal (>10kb) Multiome | 109 | |
| chr10:117,374,572–117,376,277 | 80 bp | At TSS Multiome | 881 | |
| chr10:117,376,371–117,376,684 | 931 bp | At TSS | 245 | |
| chr10:117,428,400–117,428,887 | 53.3 kb | Distal (>10kb) Multiome | 145 | |
| chr10:117,496,597–117,497,102 | 121.4 kb | Distal (>10kb) Multiome | 397 | |
| chr10:117,541,681–117,542,916 | 167.1 kb | Distal (>10kb) Multiome | 423 | |
| chr10:117,543,009–117,544,359 | 168.3 kb | Distal (>10kb) Multiome | 323 | |
| chr10:117,551,273–117,552,706 | 176.0 kb | Distal (>10kb) Multiome | 291 |
Genomic view of the PDZD8 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.