Pyruvate dehydrogenase complex (PDC) catalyzes the oxidative decarboxylation of pyruvate and links glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. The dephosphorylation and reactivation of PDC is catalyzed by pyruvate dehydrogenase phosphatase (PDP). The dimeric PDP has a catalytic subunit and a regulatory subunit. This gene encodes the FAD-containing regulatory subunit of PDP. The encoded protein acts to decrease the sensitivity of the PDP catalytic subunit to magnesium ions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for PDPR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDPR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDPR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:70,065,697–70,066,412 | 48.4 kb | Distal (>10kb) Multiome | 331 | |
| chr16:70,114,104–70,114,595 | 59 bp | At TSS Multiome | 324 | |
| chr16:70,250,987–70,252,565 | 137.5 kb | Distal (>10kb) Multiome | 1128 | |
| chr16:70,288,832–70,289,863 | 175.1 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:70,346,498–70,347,297 | 232.5 kb | Distal (>10kb) Multiome | 945 | |
| chr16:70,380,270–70,382,056 | 267.1 kb | Distal (>10kb) Multiome | 1036 |
Genomic view of the PDPR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.