The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PDLIM7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDLIM7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDLIM7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:177,303,008–177,304,238 | 193.2 kb | Distal (>10kb) Multiome | 850 | |
| chr5:177,309,549–177,310,172 | 187.0 kb | Distal (>10kb) Multiome | 373 | |
| chr5:177,311,267–177,313,178 | 184.6 kb | Distal (>10kb) Multiome | 798 | |
| chr5:177,351,374–177,352,243 | 145.0 kb | Distal (>10kb) Multiome | 832 | |
| chr5:177,362,756–177,363,624 | 133.7 kb | Distal (>10kb) Multiome | 479 | |
| chr5:177,366,082–177,368,548 | 129.7 kb | Distal (>10kb) Multiome | 626 | |
| chr5:177,370,255–177,371,449 | 126.0 kb | Distal (>10kb) Multiome | 584 | |
| chr5:177,402,327–177,404,671 | 92.4 kb | Distal (>10kb) Multiome | 807 | |
| chr5:177,425,334–177,427,296 | 70.4 kb | Distal (>10kb) Multiome | 982 | |
| chr5:177,446,196–177,448,203 | 50.1 kb | Distal (>10kb) Multiome | 826 | |
| chr5:177,453,910–177,456,838 | 41.4 kb | Distal (>10kb) Multiome | 1057 | |
| chr5:177,457,280–177,458,365 | 39.1 kb | Distal (>10kb) Multiome | 321 | |
| chr5:177,472,252–177,474,487 | 24.2 kb | Distal (>10kb) Multiome | 546 | |
| chr5:177,491,301–177,491,987 | 5.3 kb | Proximal (<10kb) Multiome | 522 | |
| chr5:177,494,661–177,498,477 | 1.2 kb | Proximal (<10kb) Multiome | 915 | |
| chr5:177,500,863–177,501,460 | 4.3 kb | Proximal (<10kb) Multiome | 378 | |
| chr5:177,516,515–177,517,551 | 20.2 kb | Distal (>10kb) Multiome | 958 | |
| chr5:177,553,719–177,554,931 | 57.7 kb | Distal (>10kb) Multiome | 671 | |
| chr5:177,591,993–177,592,765 | 95.3 kb | Distal (>10kb) Multiome | 724 | |
| chr5:177,599,409–177,600,500 | 103.2 kb | Distal (>10kb) Multiome | 871 | |
| chr5:177,607,310–177,608,120 | 110.8 kb | Distal (>10kb) Multiome | 392 |
Genomic view of the PDLIM7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.