This gene encodes a member of the enigma protein family. The protein contains two protein interacting domains, a PDZ domain at the amino terminal end and one to three LIM domains at the carboxyl terminal. It is a cytoplasmic protein associated with the cytoskeleton. The protein may function as an adapter to bring other LIM-interacting proteins to the cytoskeleton. Pseudogenes associated with this gene are located on chromosomes 3, 14 and 17. [provided by RefSeq, Oct 2012]
Transcription factors with Perturb-seq knockdown data for PDLIM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDLIM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDLIM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:94,622,339–94,624,054 | 668.0 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr10:95,183,273–95,184,294 | 107.3 kb | Distal (>10kb) Multiome | 664 | |
| chr10:95,230,238–95,231,843 | 59.8 kb | Distal (>10kb) Multiome | 334 | |
| chr10:95,260,477–95,261,004 | 30.3 kb | Distal (>10kb) Multiome | 310 | |
| chr10:95,263,812–95,265,078 | 26.4 kb | Distal (>10kb) Multiome | 233 | |
| chr10:95,289,276–95,289,909 | 1.5 kb | Proximal (<10kb) Multiome | 302 | |
| chr10:95,290,409–95,291,390 | 55 bp | At TSS Multiome | 671 | |
| chr10:95,295,036–95,295,698 | 4.0 kb | Proximal (<10kb) | 334 | |
| chr10:95,305,545–95,306,494 | 15.0 kb | Distal (>10kb) Multiome | 125 | |
| chr10:95,312,976–95,313,538 | 22.2 kb | Distal (>10kb) Multiome | 108 | |
| chr10:95,332,677–95,333,436 | 42.0 kb | Distal (>10kb) Multiome | 42 | |
| chr10:95,425,771–95,426,669 | 135.2 kb | Distal (>10kb) Multiome | 202 | |
| chr10:95,560,414–95,561,730 | 270.4 kb | Distal (>10kb) Multiome | 707 |
Genomic view of the PDLIM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.