This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for PDIA4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDIA4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDIA4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:148,883,285–148,885,276 | 144.3 kb | Distal (>10kb) Multiome | 917 | |
| chr7:148,940,713–148,941,315 | 87.6 kb | Distal (>10kb) Multiome | 792 | |
| chr7:148,966,846–148,967,346 | 61.6 kb | Distal (>10kb) Multiome | 532 | |
| chr7:148,982,929–148,984,226 | 45.0 kb | Distal (>10kb) Multiome | 671 | |
| chr7:148,987,066–148,988,336 | 41.2 kb | Distal (>10kb) Multiome | 765 | |
| chr7:149,027,878–149,029,294 | 78 bp | At TSS Multiome | 992 | |
| chr7:149,065,040–149,066,286 | 37.2 kb | Distal (>10kb) Multiome | 971 | |
| chr7:149,071,460–149,072,205 | 43.3 kb | Distal (>10kb) Multiome | 300 | |
| chr7:149,090,124–149,091,686 | 62.1 kb | Distal (>10kb) Multiome | 1010 | |
| chr7:149,125,518–149,127,217 | 97.6 kb | Distal (>10kb) Multiome | 1147 | |
| chr7:149,145,364–149,146,036 | 117.0 kb | Distal (>10kb) Multiome | 220 | |
| chr7:149,147,030–149,148,737 | 118.7 kb | Distal (>10kb) Multiome | 938 | |
| chr7:149,194,998–149,196,417 | 166.9 kb | Distal (>10kb) Multiome | 917 | |
| chr7:149,239,406–149,240,188 | 211.0 kb | Distal (>10kb) Multiome | 889 | |
| chr7:149,261,689–149,262,807 | 233.5 kb | Distal (>10kb) Multiome | 905 | |
| chr7:149,284,774–149,286,087 | 256.5 kb | Distal (>10kb) Multiome | 499 |
Genomic view of the PDIA4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.