This gene encodes a 59 kDa protein that is associated with the U11 small nuclear ribonucleoprotein (snRNP), which is a component of the minor U12-type spliceosome responsible for catalyzing pre-mRNA splicing of U12-type introns. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for PDCD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PDCD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PDCD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:64,840,757–64,843,201 | 292.2 kb | Distal (>10kb) Multiome | 732 | |
| chr15:64,893,790–64,894,635 | 239.6 kb | Distal (>10kb) Multiome | 506 | |
| chr15:64,905,276–64,905,958 | 228.2 kb | Distal (>10kb) Multiome | 362 | |
| chr15:64,911,481–64,912,188 | 222.0 kb | Distal (>10kb) Multiome | 308 | |
| chr15:64,915,576–64,916,281 | 217.9 kb | Distal (>10kb) Multiome | 115 | |
| chr15:64,989,345–64,990,371 | 143.9 kb | Distal (>10kb) Multiome | 859 | |
| chr15:65,028,915–65,029,974 | 104.2 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,049,359–65,049,794 | 84.3 kb | Distal (>10kb) Multiome | 267 | |
| chr15:65,067,081–65,068,384 | 65.7 kb | Distal (>10kb) Multiome | 131 | |
| chr15:65,101,638–65,102,425 | 31.9 kb | Distal (>10kb) Multiome | 204 | |
| chr15:65,132,889–65,133,960 | 67 bp | At TSS Multiome | 775 | |
| chr15:65,184,434–65,185,938 | 51.7 kb | Distal (>10kb) Multiome | 985 | |
| chr15:65,286,029–65,287,330 | 153.1 kb | Distal (>10kb) Multiome | 919 | |
| chr15:65,295,595–65,297,682 | 162.5 kb | Distal (>10kb) Multiome | 1039 | |
| chr15:65,299,879–65,301,676 | 167.2 kb | Distal (>10kb) Multiome | 464 | |
| chr15:65,303,709–65,305,825 | 171.1 kb | Distal (>10kb) Multiome | 1230 | |
| chr15:65,355,116–65,356,095 | 221.8 kb | Distal (>10kb) Multiome | 288 | |
| chr15:65,376,859–65,378,657 | 244.2 kb | Distal (>10kb) Multiome | 612 | |
| chr15:65,384,869–65,386,083 | 252.0 kb | Distal (>10kb) Multiome | 703 | |
| chr15:65,400,812–65,401,824 | 267.6 kb | Distal (>10kb) Multiome | 406 | |
| chr15:65,414,873–65,415,582 | 281.5 kb | Distal (>10kb) Multiome | 333 | |
| chr15:65,421,061–65,422,050 | 287.7 kb | Distal (>10kb) Multiome | 457 | |
| chr15:65,422,462–65,423,579 | 289.3 kb | Distal (>10kb) Multiome | 450 |
Genomic view of the PDCD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.