Enables collagen binding activity; heparin binding activity; and peptidase activator activity. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in extracellular region. Predicted to be part of collagen trimer. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PCOLCE2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCOLCE2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCOLCE2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:142,595,928–142,596,960 | 292.8 kb | Distal (>10kb) Multiome | 962 | |
| chr3:142,723,641–142,725,348 | 164.9 kb | Distal (>10kb) Multiome | 876 | |
| chr3:142,863,026–142,863,734 | 25.9 kb | Distal (>10kb) Multiome | 186 | |
| chr3:142,866,818–142,867,310 | 22.1 kb | Distal (>10kb) Multiome | 187 | |
| chr3:142,888,221–142,889,512 | 380 bp | At TSS Multiome | 691 | |
| chr3:142,962,519–142,964,437 | 74.4 kb | Distal (>10kb) Multiome | 781 | |
| chr3:143,000,964–143,002,299 | 112.3 kb | Distal (>10kb) Multiome | 1014 | |
| chr3:143,118,976–143,122,095 | 232.2 kb | Distal (>10kb) Multiome | 740 |
Genomic view of the PCOLCE2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.