Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in protein modification process. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for PCMTD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PCMTD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PCMTD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:63,955,375–63,956,875 | 299.4 kb | Distal (>10kb) Multiome | 1107 | |
| chr20:63,956,976–63,958,127 | 298.1 kb | Distal (>10kb) Multiome | 709 | |
| chr20:63,969,149–63,970,667 | 285.8 kb | Distal (>10kb) Multiome | 764 | |
| chr20:63,973,660–63,974,150 | 281.8 kb | Distal (>10kb) Multiome | 767 | |
| chr20:63,980,541–63,981,488 | 274.6 kb | Distal (>10kb) Multiome | 986 | |
| chr20:64,030,226–64,031,221 | 225.0 kb | Distal (>10kb) Multiome | 159 | |
| chr20:64,038,338–64,039,469 | 216.6 kb | Distal (>10kb) Multiome | 628 | |
| chr20:64,047,989–64,049,987 | 206.3 kb | Distal (>10kb) Multiome | 541 | |
| chr20:64,053,902–64,054,682 | 201.5 kb | Distal (>10kb) Multiome | 609 | |
| chr20:64,057,481–64,058,099 | 197.9 kb | Distal (>10kb) Multiome | 659 | |
| chr20:64,062,561–64,063,881 | 192.7 kb | Distal (>10kb) Multiome | 991 | |
| chr20:64,079,311–64,080,472 | 175.8 kb | Distal (>10kb) Multiome | 688 | |
| chr20:64,083,392–64,084,408 | 172.0 kb | Distal (>10kb) Multiome | 591 | |
| chr20:64,101,897–64,102,924 | 153.4 kb | Distal (>10kb) Multiome | 457 | |
| chr20:64,160,199–64,160,889 | 95.3 kb | Distal (>10kb) Multiome | 55 | |
| chr20:64,255,171–64,256,183 | 115 bp | At TSS Multiome | 861 |
Genomic view of the PCMTD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.